Results 41 to 50 of about 470,574 (313)
Effectiveness of a local recruitment registry in older adults in Southern California
BMC Medical Research MethodologyBackground Despite their potential as tools for improving the efficiency of accrual in clinical research, few analyses have assessed the effectiveness of recruitment registries.
Adam I. Birnbaum +5 more
doaj +1 more source
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease
Neurobiology of Disease, 2013 Alzheimer's disease (AD) afflicts more than 5.4 million Americans and ranks as the most common type of dementia (Thies and Bleiler, 2011), yet effective pharmacological treatments have not been identified.
Karlie A. Intlekofer, Carl W. Cotman
doaj +1 more source
Frontiers in Medicine, 2020 Reluctance to undergo lumbar puncture (LP) is a barrier to neurological disease biomarker research. We assessed whether an educational intervention increased willingness to consider research LP and whether message framing modified intervention ...
Megan G. Witbracht +13 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition
Neurobiology of Disease, 2014 Recent studies on tauopathy animal models suggest that the concomitant expression of the endogenous murine tau delays the pathological accumulation of human tau, and interferes with the disease progression.
David Baglietto-Vargas +7 more
doaj +1 more source
Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40
Alzheimer’s Research & Therapy, 2020 Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid β-protein (Aβ) and the microtubule-associated protein, tau, and has been genetically linked to late-onset Alzheimer disease (AD).
Caitlin N. Suire +8 more
doaj +1 more source
Children's basic memory processes, stress and maltreatment [PDF]
, 2006 Building upon methods and research utilized with normative populations, we examine extant assumptions regarding the effects of child maltreatment on memory.
Howe, Mark L. +2 more
core
Using the yes/no recognition response pattern to detect memory malingering
, 2013 Schindler S, Kißler J, Kühl K-P, Hellweg R, Bengner T. Using the yes/no recognition response pattern to detect memory malingering. BMC Psychology.
Hellweg, Rainer +4 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Frontiers in Aging Neuroscience, 2022 ObjectiveValidation and widespread use of markers indicating decline in serial neuropsychological exams has remained elusive despite potential value in prognostic and treatment decision-making.
Jean K. Ho +2 more
doaj +1 more source