Results 41 to 50 of about 3,414,631 (292)

Reading comprehension in developmental disorders of language and communication [PDF]

, 2011
Background:  Deficits in reading airment (SLI), Down syndrome (DS) and autism spectrum disorders (ASD). Methods:  In this review (based on a search of the ISI Web of Knowledge database to 2011), the Simple View of Reading is used as a framework for ...
Ricketts, Jessie, Jessie Ricketts
core   +1 more source

Cross‐sectional associations of migration‐related indicators and research attitudes in underrepresented populations being recruited for a preclinical Alzheimer's disease trial

Alzheimer’s & Dementia: Behavior & Socioeconomics of Aging
Introduction Factors shaping research attitudes among immigrant and later‐generation adults from racial and ethnic groups underrepresented in Alzheimer's disease (AD) research remain poorly understood.
Christian R. Salazar, Edwin Duran, Melanie Tallakson, Maria G. Corona, Eunji Russ, Romina A. Romero, David L. Sultzer, Joshua D. Grill, Hye‐Won Shin   +8 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effectiveness of a local recruitment registry in older adults in Southern California

BMC Medical Research Methodology
Background Despite their potential as tools for improving the efficiency of accrual in clinical research, few analyses have assessed the effectiveness of recruitment registries.
Adam I. Birnbaum, Adrijana Gombosev, Zion T. Grant-Freeman, Dan Hoang, Daniel L. Gillen, Joshua D. Grill   +5 more
doaj   +1 more source

Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta

Neurobiology of Disease, 2010
Previously we showed that anti-Aβ peptide immunotherapy significantly attenuated Alzheimer's-like amyloid deposition in the central nervous system of aged canines.
Vitaly Vasilevko, Viorela Pop, Hyun Jin Kim, Tommy Saing, Charles C. Glabe, Saskia Milton, Edward G. Barrett, Carl W. Cotman, David H. Cribbs, Elizabeth Head   +9 more
doaj   +1 more source

Education and Message Framing Increase Willingness to Undergo Research Lumbar Puncture: A Randomized Controlled Trial

Frontiers in Medicine, 2020
Reluctance to undergo lumbar puncture (LP) is a barrier to neurological disease biomarker research. We assessed whether an educational intervention increased willingness to consider research LP and whether message framing modified intervention ...
Megan G. Witbracht, Olivia M. Bernstein, Vanessa Lin, Christian R. Salazar, S. Ahmad Sajjadi, S. Ahmad Sajjadi, Dan Hoang, Chelsea G. Cox, Daniel L. Gillen, Daniel L. Gillen, Joshua D. Grill, Joshua D. Grill, Joshua D. Grill, Joshua D. Grill   +13 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Hormonal and genetic modulation of memory processes in healthy humans: focus on cortisol and "HDAC5" [PDF]

, 2015
Individual differences in memory performance can be due to the influence of various hormones as well as genetic variations and epigenetic modifications.
Hartmann, Francina
core   +1 more source

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

Neurobiology of Disease, 2013
Alzheimer's disease (AD) afflicts more than 5.4 million Americans and ranks as the most common type of dementia (Thies and Bleiler, 2011), yet effective pharmacological treatments have not been identified.
Karlie A. Intlekofer, Carl W. Cotman
doaj   +1 more source

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

Alzheimer’s Research & Therapy, 2020
Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid β-protein (Aβ) and the microtubule-associated protein, tau, and has been genetically linked to late-onset Alzheimer disease (AD).
Caitlin N. Suire, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Monica K. Brizuela, Paul Saftig, Dennis W. Dickson, Terrone L. Rosenberry, Malcolm A. Leissring   +8 more
doaj   +1 more source