Results 41 to 50 of about 3,905,908 (191)

Human Organic Memory Disorders

open access: yes, 1988
Brain damage can cause memory to break down in a number of different ways, the analysis of which can illuminate how the intact brain mediates memory processes.
Andrew R. Mayes
core   +1 more source

Cross‐sectional associations of migration‐related indicators and research attitudes in underrepresented populations being recruited for a preclinical Alzheimer's disease trial

open access: yesAlzheimer’s & Dementia: Behavior & Socioeconomics of Aging
Introduction Factors shaping research attitudes among immigrant and later‐generation adults from racial and ethnic groups underrepresented in Alzheimer's disease (AD) research remain poorly understood.
Christian R. Salazar   +8 more
doaj   +1 more source

Selective vulnerabilities and biomarkers in neurocognitive aging [version 1; referees: 4 approved]

open access: yesF1000Research, 2017
As the world’s population continues to age, an understanding of the aging brain becomes increasingly crucial. This review focuses on several recent ideas and findings in the study of neurocognitive aging, specifically focusing on episodic memory, and ...
Zachariah Reagh, Michael Yassa
doaj   +1 more source

Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta

open access: yesNeurobiology of Disease, 2010
Previously we showed that anti-Aβ peptide immunotherapy significantly attenuated Alzheimer's-like amyloid deposition in the central nervous system of aged canines.
Vitaly Vasilevko   +9 more
doaj   +1 more source

Effectiveness of a local recruitment registry in older adults in Southern California

open access: yesBMC Medical Research Methodology
Background Despite their potential as tools for improving the efficiency of accrual in clinical research, few analyses have assessed the effectiveness of recruitment registries.
Adam I. Birnbaum   +5 more
doaj   +1 more source

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

open access: yesNeurobiology of Disease, 2013
Alzheimer's disease (AD) afflicts more than 5.4 million Americans and ranks as the most common type of dementia (Thies and Bleiler, 2011), yet effective pharmacological treatments have not been identified.
Karlie A. Intlekofer, Carl W. Cotman
doaj   +1 more source

The entorhinal spatial map integrates visual identity information of landmarks

open access: yesNature Communications
Landmarks guide navigation by providing information through their location and identity. The medial entorhinal cortex (MEC) is well known for representing landmark location, but whether it also encodes landmark identity remains unclear.
Garret Wang   +6 more
doaj   +1 more source

Education and Message Framing Increase Willingness to Undergo Research Lumbar Puncture: A Randomized Controlled Trial

open access: yesFrontiers in Medicine, 2020
Reluctance to undergo lumbar puncture (LP) is a barrier to neurological disease biomarker research. We assessed whether an educational intervention increased willingness to consider research LP and whether message framing modified intervention ...
Megan G. Witbracht   +13 more
doaj   +1 more source

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

open access: yesAlzheimer’s Research & Therapy, 2020
Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid β-protein (Aβ) and the microtubule-associated protein, tau, and has been genetically linked to late-onset Alzheimer disease (AD).
Caitlin N. Suire   +8 more
doaj   +1 more source

Kikuchi–Fujimoto disease associated with the central nervous system in children

open access: yesPediatric Discovery, 2023
The clinical data of patients with Kikuchi–Fujimoto disease (KFD) combined with the involvement of the central system is limited, particularly for children.
Yuyao Huang   +7 more
doaj   +1 more source

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