Results 31 to 40 of about 470,574 (313)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Selective vulnerabilities and biomarkers in neurocognitive aging [version 1; referees: 4 approved]

F1000Research, 2017
As the world’s population continues to age, an understanding of the aging brain becomes increasingly crucial. This review focuses on several recent ideas and findings in the study of neurocognitive aging, specifically focusing on episodic memory, and ...
Zachariah Reagh, Michael Yassa
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Subjective Experience of Episodic Memory and Metacognition: A Neurodevelopmental Approach

, 2013
Episodic retrieval is characterized by the subjective experience of remembering. This experience enables the co-ordination of memory retrieval processes and can be acted on metacognitively.
Katalin Pauly-Takacs, Francis eEustache, Bérengère Guillery-Girard, Katalin ePauly-Takacs, Souchay, C, Eustache, F, Francis Eustache, Wojcik, DZ, Pauly-Takacs, K, Celine eSouchay, Berengere eGuillery-Girard, Dominika Zofia Wojcik, Guillery-Girard, B, Céline Souchay   +13 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta

Neurobiology of Disease, 2010
Previously we showed that anti-Aβ peptide immunotherapy significantly attenuated Alzheimer's-like amyloid deposition in the central nervous system of aged canines.
Vitaly Vasilevko, Viorela Pop, Hyun Jin Kim, Tommy Saing, Charles C. Glabe, Saskia Milton, Edward G. Barrett, Carl W. Cotman, David H. Cribbs, Elizabeth Head   +9 more
doaj   +1 more source

CMIP and ATP2C2 Modulate Phonological Short-Term Memory in Language Impairment [PDF]

, 2009
Specific language impairment (SLI) is a common developmental disorder characterized by difficulties in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors.
Dworzynski, K., Helms, P., Dorothy V.M. Bishop, Helms, Peter J., Newbury, D., Hennessy, E, Addis, Laura, Andrea Everitt, Pickles, A, Seckl, J, Addis, L., Buckingham, Lyn-Louise, Helms, P. J., Anne O'Hare, Bishop, Dorothy V.M., Slonims, V., Emily Simonoff, Silvia Paracchini, Andrew Pickles, Slonims, Vicky, O'Hare, A, Simkin, Z, Simonoff, Emily, Duncan Shaw, Winchester, L, Pickles, A., Kindley, AD, Everitt, A., Vicky Slonims, Seckl, J. R., Bishop, DV, Clark, Ann, Gina Conti-Ramsden, Cohen, W., Buckingham, L., Conti-Ramsden, G., Hilary Cowie, Monaco, Anthony P., Seckl, J., Baird, Gillian, Cowie, Hilary, Newbury, D F, Hennessy, E., Newbury, D. F., Goodyer, Ian M., Baird, G., Katharina Dworzynski, Laura Winchester, Cohen, Wendy, Laura Addis, Buckingham, LL, Kindley, A. D., Hennessy, Elizabeth, Nasir, J., Helms, PJ, Conti-Ramsden, Gina, Bishop, D., Fisher, Simon, Paracchini, S, Goodyer, IM, Dworzynski, KD, Everitt, Andrea, Pickles, Andrew, Clark, A, Jamal Nasir, Jiannis Ragoussis, Shaw, D., Siminoff, E, Newbury, DF, Bolton, Patrick F., Lyn-Louise Buckingham, Paracchini, S., Dianne F. Newbury, Simkin, Zoe, Fisher, S. E., Anthony P. Monaco, Simkin, Z., Goodyer, I. M., Goodyer, I., Buckingham, Lyn Louise, Zoe Simkin, Miller, Laura L., O'Hare, A., Ian M. Goodyer, Ragoussis, J., Clark, A., Miller, L. L., Simonoff, Emily; id_orcid, Ragoussis, Jiannis, Wendy Cohen, Nasir, J, Ann Clark, Miller, LL, Dworzynski, Katharina, Seckl, JR, Monaco, AP, Ragoussis, Ioannis, Seckl, Jonathon R., Simon E. Fisher, Patrick F. Bolton, O'Hare, Anne, Shaw, D, Addis, L, Bishop, D. V. M., Ragoussis, J, Everitt, A, Watson, J, Peter J. Helms, Cowie, H., Cohen, W, Miller, L., Monaco, A., Paracchini, Silvia, Watson, J., Bolton, PF, Newbury, Dianne, Bolton, P. F., Buckingham, L. L., Shaw, Darren, Monaco, Anthony, Bishop, Dorothy V. M., Miller, Laura L, Jocelynne Watson, Dworzynski, K, Kindley, A. David, Kindley, A., A. David Kindley, Laura L. Miller, Baird, G, Fisher, S., Bolton, P., Fisher, SE, Conti-Ramsden, G, Cowie, H, Monaco, A. P., Slonims, V, Nasir, Jamal, Winchester, L., Bishop, DVM, Watson, Jocelynne, Newbury, Dianne F., Simonoff, E, Winchester, Laura, Jonathon R. Seckl, Gillian Baird, Simonoff, E., Fisher, Simon E., Elizabeth Hennessy, Bishop, Dorothy, Shaw, Duncan   +149 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source