Results 11 to 20 of about 442,344 (263)

Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

Scientific Reports, 2022
Blood pressure variability is an emerging risk factor for Alzheimer’s disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer’s disease pathophysiology ...
Isabel J. Sible, Belinda Yew, Jung Yun Jang, John Paul M. Alitin, Yanrong Li, Aimée Gaubert, Amy Nguyen, Shubir Dutt, Anna E. Blanken, Jean K. Ho, Anisa J. Marshall, Arunima Kapoor, Fatemah Shenasa, Kathleen E. Rodgers, Virginia E. Sturm, Elizabeth Head, Alessandra Martini, Daniel A. Nation   +17 more
doaj   +1 more source

SENSory re-learning of the UPPer limb (SENSUPP) after stroke: development and description of a novel intervention using the TIDieR checklist

Trials, 2021
Background Sensorimotor impairments of upper limb (UL) are common after stroke, leading to difficulty to use the UL in daily life. Even though many have sensory impairments in the UL, specific sensory training is often lacking in stroke rehabilitation ...
Håkan Carlsson, Birgitta Rosén, Anders Björkman, Hélène Pessah-Rasmussen, Christina Brogårdh   +4 more
doaj   +1 more source

Racial and ethnic differences in older adults’ willingness to be contacted about Alzheimer's disease research participation

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction We sought to examine the association of race/ethnicity with willingness to engage in studies that involve procedures typical of Alzheimer's disease (AD) clinical trials and determine whether any observed differences could be explained by ...
Christian R. Salazar, Dan Hoang, Daniel L. Gillen, Joshua D. Grill   +3 more
doaj   +1 more source

Quantitative, High-Throughput Assays for Proteolytic Degradation of Amylin

Methods and Protocols, 2020
Amylin is a pancreatic peptide hormone that regulates glucose homeostasis but also aggregates to form islet amyloid in type-2 diabetes. Given its role in both health and disease, there is renewed interest in proteolytic degradation of amylin by insulin ...
Caitlin N. Suire, Monica K. Brizuela, Malcolm A. Leissring   +2 more
doaj   +1 more source

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease

Scientific Data, 2021
Measurement(s) Protein Expression • gene expression • electrophysiology data • protein measurement • behavior Technology Type(s) immunofluorescence microscopy assay • RNA sequencing • electrophysiology assay • Electrochemiluminescence Immunoassay ...
Stefania Forner, Shimako Kawauchi, Gabriela Balderrama-Gutierrez, Enikö A. Kramár, Dina P. Matheos, Jimmy Phan, Dominic I. Javonillo, Kristine M. Tran, Edna Hingco, Celia da Cunha, Narges Rezaie, Joshua A. Alcantara, David Baglietto-Vargas, Camden Jansen, Jonathan Neumann, Marcelo A. Wood, Grant R. MacGregor, Ali Mortazavi, Andrea J. Tenner, Frank M. LaFerla, Kim N. Green   +20 more
doaj   +1 more source

Targeted Control of Gene Expression Using CRISPR-Associated Endoribonucleases

Cells
CRISPR-associated endoribonucleases (Cas RNases) cleave single-stranded RNA in a highly sequence-specific manner by recognizing and binding to short RNA sequences known as direct repeats (DRs).
Sagar J. Parikh, Heather M. Terron, Luke A. Burgard, Derek S. Maranan, Dylan D. Butler, Abigail Wiseman, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring   +8 more
doaj   +1 more source

Protocol for single-nucleus ATAC sequencing and bioinformatic analysis in frozen human brain tissue

STAR Protocols, 2022
Summary: Single-nucleus ATAC sequencing (snATAC-seq) employs a hyperactive Tn5 transposase to gain precise information about the cis-regulatory elements in specific cell types. However, the standard protocol of snATAC-seq is not optimized for all tissues,
Zechuan Shi, Sudeshna Das, Samuel Morabito, Emily Miyoshi, Vivek Swarup   +4 more
doaj   +1 more source

5′ DREDGE: Direct Repeat-Enabled Downregulation of Gene Expression via the 5′ UTR of Target Genes

Cells
Despite the availability of numerous methods for controlling gene expression, there remains a strong need for technologies that maximize two key properties: selectivity and reversibility.
Sagar J. Parikh, Heather M. Terron, Luke A. Burgard, Dylan D. Butler, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring   +6 more
doaj   +1 more source

Communicating mild cognitive impairment diagnoses with and without amyloid imaging

Alzheimer’s Research & Therapy, 2017
Background Mild cognitive impairment (MCI) has an uncertain etiology and prognosis and may be challenging for clinicians to discuss with patients and families.
Joshua D. Grill, Liana G. Apostolova, Szofia Bullain, Jeffrey M. Burns, Chelsea G. Cox, Malcolm Dick, Dean Hartley, Claudia Kawas, Sarah Kremen, Jennifer Lingler, Oscar L. Lopez, Mark Mapstone, Aimee Pierce, Gil Rabinovici, J. Scott Roberts, Seyed Ahmad Sajjadi, Edmond Teng, Jason Karlawish   +17 more
doaj   +1 more source

Medial Temporal Lobe Contributions to Future Thinking: Evidence from Neuroimaging and Amnesia

Psychologica Belgica, 2012
Following early amnesic case reports, there is now considerable evidence suggesting a link between remembering the past and envisioning the future. This link is evident in the overlap in neural substrates as well as cognitive processes involved in both ...
Mieke Verfaellie, Elizabeth Race, Margaret M Keane   +2 more
doaj   +1 more source