Results 11 to 20 of about 3,905,908 (191)

Working memory in children with developmental disorders [PDF]

open access: yes, 2009
The aim of the present study was to directly compare working memory skills across students with different developmental disorders to investigate whether the uniqueness of their diagnosis would impact memory skills.
Tracy, Alloway   +6 more
core   +4 more sources

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology

open access: yesNature Communications, 2021
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelling some
David Baglietto-Vargas   +34 more
doaj   +1 more source

Reasons for undergoing amyloid imaging among cognitively unimpaired older adults

open access: yesAnnals of Clinical and Translational Neurology, 2021
Objectives Preclinical Alzheimer’s disease (AD) clinical trials screen cognitively unimpaired older adults for biomarker criteria and disclose their results.
Mary M. Ryan   +2 more
doaj   +1 more source

Emotional processing and episodic memory. [PDF]

open access: yes
The research reported within this dissertation investigates how individuals’ capacity to assimilate emotionally disruptive events is associated with particular features of episodic and autobiographical memory formation. It is inspired by Rachman’s (1980,
Howells, Glen
core   +6 more sources

Recruitment across two decades of NIH-funded Alzheimer’s disease clinical trials

open access: yesAlzheimer’s Research & Therapy, 2023
Background Timely accrual of a representative sample is a key factor in whether Alzheimer’s disease (AD) clinical trials successfully answer the scientific questions under study.
Marina Ritchie   +2 more
doaj   +1 more source

Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials

open access: yesAlzheimer’s Research & Therapy, 2023
Background Participant retention is a key factor that affects clinical trial integrity. Trial protocols estimate attrition as a function of sample size calculations. Alzheimer’s disease (AD) is an area of active treatment development.
Marina Ritchie   +2 more
doaj   +1 more source

Microglial APOE4: more is less and less is more

open access: yesMolecular Neurodegeneration, 2023
Apolipoprotein E (APOE) is the single greatest genetic risk factor for late onset Alzheimer’s disease (AD). Yet, the cell-specific effects of APOE on microglia function have remained unclear.
Ghazaleh Eskandari-Sedighi   +1 more
doaj   +1 more source

Children's basic memory processes, stress and maltreatment [PDF]

open access: yes, 2006
Building upon methods and research utilized with normative populations, we examine extant assumptions regarding the effects of child maltreatment on memory.
Howe, Mark L.   +2 more
core   +4 more sources

IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation

open access: yesJournal of Neuroinflammation, 2018
Background Brain inflammation including increases in inflammatory cytokines such as IL-1β is widely believed to contribute to the pathophysiology of Alzheimer’s disease.
Liqi Tong   +2 more
doaj   +1 more source

Study partner types and prediction of cognitive performance: implications to preclinical Alzheimer’s trials

open access: yesAlzheimer’s Research & Therapy, 2019
Background Alzheimer’s disease (AD) clinical trials require enrollment of a participant and a study partner, whose role includes assessing participant cognitive and functional performance.
Michelle M. Nuño   +3 more
doaj   +1 more source

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