Results 41 to 50 of about 2,827,438 (300)

Gait characteristics in older adults using the ProtoKinetics Zeno walkway: the atherosclerosis risk in communities (ARIC) study

Frontiers in Aging Neuroscience
BackgroundGait speed is an important indicator of functional status and health outcomes in older adults. Electronic gait mats are common in research, but stopwatches are more feasible in clinical practice.
Katherine J. Hunzinger, Laura Skow, Andrea L. C. Schneider, Andrea L. C. Schneider, Michael E. Griswold, Xiaoqian Zhu, Farwa Ali, Pamela L. Lutsey, Jennifer A. Schrack, Luigi Ferrucci, Eleanor M. Simonsick, B. Gwen Windham   +11 more
doaj   +1 more source

Memory Performance in Patient with Systemic Lupus Erythematosus Using MoCA-Ina in Hasan Sadikin Genneral Hospital Bandung

Indonesian Journal of Rheumatology, 2018
Background: The involvement of neuropsychiatry is reported in 6% to 91% of Systemic Lupus Erythematosus (SLE) patients. It can cause fatal morbidity and mortality. Memory impairment is one of the most common symptoms of neuropsychiatry involvement.
Safira Anjalia, Paulus Anam Ong, Nur Atik, Laniyati Hamijoyo   +3 more
doaj   +1 more source

Verbal Memory Impairments in Dyslexia [PDF]

Archives of Clinical Neuropsychology, 2000
Although verbal memory deficits are frequently reported in reading disabled children, the specific mechanisms underlying these impairments have yet to be clearly defined. The present study used the California Verbal Learning Test-Children's Version (CVLT-C) to assess verbal learning in 57 dyslexic children and 114 controls matched for gender, age, and ...
J H, Kramer, K, Knee, D C, Delis
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Patterns of Factors in the National Institute on Aging Health Disparities Research Framework Domains and Mild Cognitive Impairment Risk

AJPM Focus
Introduction: Alzheimer's disease and related dementias are public health and social care challenges. This study used the National Institute on Aging Health Disparities Research Framework to organize potential cognitive impairment risk factors.
Maria Vassilaki, MD, PhD, Jeremiah A. Aakre, MPH, Timothy G. Lesnick, MS, Walter K. Kremers, PhD, Jonathan Graff-Radford, MD, David S. Knopman, MD, Thomas H. Mosley, PhD, B. Gwen Windham, MD, MHS, Michael E. Griswold, PhD, Yonas E. Geda, MD, MSc, Val J. Lowe, MD, Clifford R. Jack, Jr., MD, Ronald C. Petersen, MD, PhD, Prashanthi Vemuri, PhD   +13 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Patterns of Semantic Memory Impairment in Mild Cognitive Impairment [PDF]

Behavioural Neurology, 2008
Although the semantic memory impairment has been largely documented in Alzheimer′s disease, little is known about semantic memory in the preclinical phase of the disease (Mild Cognitive Impairment). The purpose of this study was to document the nature of semantic breakdown using a battery of tests assessing different aspects of conceptual knowledge ...
Joubert, Sven, Felician, Olivier, Barbeau, Emmanuel J, Didic, Mira, Poncet, Michel, Ceccaldi, Mathieu   +5 more
openaire   +4 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Associations of Midlife Vascular Risk Factors With Late‐Life Depressive Symptoms: Findings From the ARIC Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The impact of midlife vascular health, which is strongly linked with other aspects of brain health, on late‐life depression is not well understood.
Sylee Kanetkar, Valerie N. Morrill, Marco T. Egle, Keenan A. Walker, Andrea L.C. Schneider, Matthew E. Peters, Thomas H. Mosley, Srishti Shrestha, Rebecca F. Gottesman   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source