Results 51 to 60 of about 688,512 (311)

Dissociation of Alzheimer's morphological pathology from cognitive impairment [PDF]

open access: yes, 2009
We observed the Alzheimer's morphological pathology, amyloid production induces Alzheimer's cognitive impairment, was dissociated from the cognitive impairment.
Nobuyuki Mikoda, Tohru Hasegawa
core   +1 more source

Temporal properties of cerebellar-dependent memory consolidation [PDF]

open access: yes, 2004
Classical conditioning of the nictitating membrane response in rabbits is a well defined model of cerebellar-dependent motor memory. This memory undergoes a period of consolidation after the training session, when it is sensitive to reversible ...
Attwell, PJE, Cooke, SF, Yeo, CH
core   +1 more source

Verbal Memory Impairments in Dyslexia [PDF]

open access: yesArchives of Clinical Neuropsychology, 2000
Although verbal memory deficits are frequently reported in reading disabled children, the specific mechanisms underlying these impairments have yet to be clearly defined. The present study used the California Verbal Learning Test-Children's Version (CVLT-C) to assess verbal learning in 57 dyslexic children and 114 controls matched for gender, age, and ...
J H, Kramer, K, Knee, D C, Delis
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Enriched environment enhances histone acetylation of NMDA receptor in the hippocampus and improves cognitive dysfunction in aged mice

open access: yesNeural Regeneration Research, 2020
The mechanisms of age-associated memory impairment may be associated with glutamate receptor function and chromatin modification. To observe the effect of an enriched environment on the cognitive function of mice with age-associated memory impairment, 3 ...
Xin Wang   +9 more
doaj   +1 more source

When Alcoholism Affects Memory Functions: MRI of the Brain. [PDF]

open access: yes, 1995
The development of modern imaging techniques makes it possible to examine directly the relationship between brain abnormalities and memory impairment.
Jernigan, Terry L, Ostergaard, Arne L
core  

F211. Finding and fixing attentional dysfunction in schizophrenia [PDF]

open access: yes, 2018
BACKGROUND Schizophrenia is the most debilitating health problem that exists, and its cognitive impairments are the greatest predictor of disability. Since the earliest clinical descriptions of the illness, abnormalities of attention have been at the ...
Reinhart, Robert
core   +1 more source

MEMORY IMPAIRMENT IN REHABILITATION

open access: yesAustralian Journal of Physiotherapy, 1979
Memory impairment is a common problem in patients with physical disabilitiy of neurological origin. The important features of two types of memory and learning impairment, Amnesic Syndrome and Frontal Lobe Dysfunction, are briefly summarized. Emphasis is placed on the variability of signs and the possibility of new learning within these two classes of ...
openaire   +2 more sources

Memory impairment in Cushing's disease [PDF]

open access: yesActa Neurologica Scandinavica, 2009
In the present study the cognitive performance of 25 patients with Cushing's disease (CD) was extensively evaluated in comparison with normal control subjects, matched one by one. The results indicate a selective impairment of memory functions: the number of patients showing a significantly impaired mnesic performance increases with age.
MAURI, MARCO   +6 more
openaire   +3 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

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