Results 51 to 60 of about 2,507,459 (296)

Severity of memory impairment in the elderly: Association with health care resource use and functional limitations in the United States

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2017
Introduction Dementia is a prevalent condition in older adults associated with decline in cognitive and functional abilities and substantial burden.
Myrlene Sanon Aigbogun, Robert Stellhorn, Holly Krasa, Dusan Kostic   +3 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Cognitive profiles of vascular and neurodegenerative MCI [PDF]

, 2008
The objective of the thesis was to investigate the cognitive profiles of different types of mild cognitive impairment (MCI) and follow their course over time.
Nordlund, Arto
core   +1 more source

Patterns of Factors in the National Institute on Aging Health Disparities Research Framework Domains and Mild Cognitive Impairment Risk

AJPM Focus
Introduction: Alzheimer's disease and related dementias are public health and social care challenges. This study used the National Institute on Aging Health Disparities Research Framework to organize potential cognitive impairment risk factors.
Maria Vassilaki, MD, PhD, Jeremiah A. Aakre, MPH, Timothy G. Lesnick, MS, Walter K. Kremers, PhD, Jonathan Graff-Radford, MD, David S. Knopman, MD, Thomas H. Mosley, PhD, B. Gwen Windham, MD, MHS, Michael E. Griswold, PhD, Yonas E. Geda, MD, MSc, Val J. Lowe, MD, Clifford R. Jack, Jr., MD, Ronald C. Petersen, MD, PhD, Prashanthi Vemuri, PhD   +13 more
doaj   +1 more source

Subjective memory disorders and psychological distress in post COVID 19

European Psychiatry, 2023
Introduction In addition to psychological distress in patients with COVID 19, neurological and neurocognitive manifestations, such as memory impairment, are increasingly reported. Screening for cognitive impairment is therefore crucial.
N. Halouani, D. Gdoura, O. Bouattour, A. Chamseddine, N. Moussa, S. Ellouze, J. Aloulou   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Associations of Midlife Vascular Risk Factors With Late‐Life Depressive Symptoms: Findings From the ARIC Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The impact of midlife vascular health, which is strongly linked with other aspects of brain health, on late‐life depression is not well understood.
Sylee Kanetkar, Valerie N. Morrill, Marco T. Egle, Keenan A. Walker, Andrea L.C. Schneider, Matthew E. Peters, Thomas H. Mosley, Srishti Shrestha, Rebecca F. Gottesman   +8 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Enriched environment enhances histone acetylation of NMDA receptor in the hippocampus and improves cognitive dysfunction in aged mice

Neural Regeneration Research, 2020
The mechanisms of age-associated memory impairment may be associated with glutamate receptor function and chromatin modification. To observe the effect of an enriched environment on the cognitive function of mice with age-associated memory impairment, 3 ...
Xin Wang, Zhao-Xiang Meng, Ying-Zhu Chen, Yu-Ping Li, Hong-Yu Zhou, Man Yang, Ting-Ting Zhao, Yu-Lai Gong, Yi Wu, Tao Liu   +9 more
doaj   +1 more source