Results 71 to 80 of about 396,619 (367)

A Behavioural and Electrophysiological exploration of the Working Memory impairment in Developmental Dyslexia [PDF]

, 2015
The current thesis provides a behavioural and electrophysiological exploration of Working Memory (WM) processing in developmental dyslexia. This thesis identifies a debate in the literature regarding the extent to which individuals with dyslexia have a ...
Ahmad, Jumana
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Impairment of memory for spatial context in schizophrenia. [PDF]

Neuropsychology, 1996
A group of 33 patients with schizophrenia were compared with control participants using a spatial memory task in which words were presented on locations of a grid. In the first part of the experiment, recognition of target information (words) was tested.
Van der Linden, Martial, Rohmer, J.G., Rizzo, L., Grangé, D., Danion, J.M.   +4 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cognitive impairment in COPD: a systematic review

Jornal Brasileiro de Pneumologia, 2015
The objectives of this study were to characterize and clarify the relationships between the various cognitive domains affected in COPD patients and the disease itself, as well as to determine the prevalence of impairment in the various cognitive domains ...
Irene Torres-Sánchez, Elisabeth Rodríguez-Alzueta, Irene Cabrera-Martos, Isabel López-Torres, Maria Paz Moreno-Ramírez, Marie Carmen Valenza   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A low-power, distributed, pervasive healthcare system for supporting memory [PDF]

, 2011
With age, injury, or disease, human memory can be significantly impaired. Current coping strategies range from simple aids such as post-it notes and calendars to, more recently, assistive devices which attempt to provide reminders at appropriate times ...
Geoff V. Merrett, Wendy Hall, Hall, Wendy, Shadbolt, Nigel R., Alex L. Wood, Dirk de Jager, Al-Hashimi, Bashir M., O'Hara, Kieron, Kieron O'Hara, De Jager, Dirk, Merrett, Geoff V., Wood, Alex L., Bashir M. Al-Hashimi, Nigel R. Shadbolt   +13 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Association of Cerebral Autoregulation Dysfunction and Postoperative Memory Impairment in Cardiac Surgery Patients

Medicina
Background and Objectives: Cardiac surgery is associated with various durations of cerebral autoregulation (CA) impairment and can significantly impact cognitive function.
Greta Kasputytė, Birutė Kumpaitienė, Milda Švagždienė, Judita Andrejaitienė, Mindaugas Gailiušas, Edmundas Širvinskas, Arūnas Gelmanas, Yasin Hamarat, Edvinas Chaleckas, Vilma Putnynaitė, Laimonas Bartušis, Rolandas Žakelis, Vytautas Petkus, Arminas Ragauskas, Tadas Lenkutis   +14 more
doaj   +1 more source