Results 71 to 80 of about 688,512 (311)

Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tau. [PDF]

, 2020
In this study, we aimed to assess whether women are able to withstand more tau before exhibiting verbal memory impairment. Using data from 121 amyloid-β-positive Alzheimer's Disease Neuroimaging Initiative participants, we fit a linear model with Rey ...
Alzheimer’s Disease Neuroimaging Initiative, Banks, Sarah J, Brewer, James B, Digma, Leonardino A, Jacobs, Diane M, Madsen, John R, Rissman, Robert A   +6 more
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The Effects of Poetry in Elderly Populations with Memory Impairment [PDF]

, 2017
Introduction. A small body of research on therapeutic use of poetry in individuals with memory impairment demonstrates benefits similar to that of more widely studied music interventions.
Burton, Michael, Christensen, Judith, Clifford, Katherine, Corbett, John P., Eckenstein, Midori, Jorgensen, Jenna Conway, Kulaga, Stephanie S, No, Hyunsoo Joshua, White, Nathaniel   +8 more
core   +1 more source

The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats. [PDF]

, 2014
The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM.
Kilduff, Thomas S, Lincoln, Webster U, Morairty, Stephen R, Neylan, Thomas C, Wilk, Alan J   +4 more
core   +2 more sources

Astrocytes Underlie Neuroinflammatory Memory Impairment [PDF]

Cell, 2015
Neuroinflammation is being increasingly recognized as a potential mediator of cognitive impairments in various neurological conditions. Habbas et al. demonstrate that the pro-inflammatory cytokine tumor necrosis factor alpha signals through astrocytes to alter synaptic transmission and impair cognition in a mouse model of multiple sclerosis.
Osso, Lindsay A, Chan, Jonah R
openaire   +4 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study

Chinese Medical Journal, 2018
Background: Memory complaint is common in the elderly. Recently, it was shown that self-report memory complaint was predictive of cognitive decline. This study aimed to investigate the predictive value of the source of memory complaints on the risk of ...
Xue-Mei Qi, Lin Gu, Hui-Dong Tang, Sheng-Di Chen, Jian-Fang Ma   +4 more
doaj   +1 more source

Confabulation in schizophrenia: A neuropsychological study [PDF]

, 2010
Confabulation has been documented in schizophrenia, but its neuropsychological correlates appear to be different from those of confabulation in neurological disease states.
Lorente Rovira, Esther, McKenna, Peter, Moro-Ipola, Micaela, Santos Gómez, José Luis, Villagrán Moreno, José María   +4 more
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

The Association of Cerebral Autoregulation Dysfunction and Postoperative Memory Impairment in Cardiac Surgery Patients

Medicina
Background and Objectives: Cardiac surgery is associated with various durations of cerebral autoregulation (CA) impairment and can significantly impact cognitive function.
Greta Kasputytė, Birutė Kumpaitienė, Milda Švagždienė, Judita Andrejaitienė, Mindaugas Gailiušas, Edmundas Širvinskas, Arūnas Gelmanas, Yasin Hamarat, Edvinas Chaleckas, Vilma Putnynaitė, Laimonas Bartušis, Rolandas Žakelis, Vytautas Petkus, Arminas Ragauskas, Tadas Lenkutis   +14 more
doaj   +1 more source