Results 51 to 60 of about 2,374,100 (265)

Recalling gist memory depends on CA1 hippocampal neurons for lifetime retention and CA3 neurons for memory precision

Cell Reports, 2023
Summary: Why some of us remember events more clearly than others and why memory loses precision over time is a major focus in memory research. Here, we show that the recruitment of specific neuroanatomical pathways within the medial temporal lobe (MTL ...
Erika Atucha, Shih-Pi Ku, Michael T. Lippert, Magdalena M. Sauvage   +3 more
doaj   +1 more source

Memory leaks: information shared across memory systems [PDF]

Trends in Cognitive Sciences, 2022
The brain is highly segregated. Multiple mechanisms ensure that different types of memories are processed independently. Nonetheless, information leaks out across these memory systems. Only recently has the diversity of these leaks been revealed. Different memory types (skills vs.
openaire   +2 more sources

Optimal classical simulation of state-independent quantum contextuality

, 2018
Simulating quantum contextuality with classical systems requires memory. A fundamental yet open question is what is the minimum memory needed and, therefore, the precise sense in which quantum systems outperform classical ones. Here, we make rigorous the
Cabello, Adán, Gu, Mile, Gühne, Otfried, Xu, Zhen-Peng   +3 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Violation of the ultrastructural size principle in the dorsolateral prefrontal cortex underlies working memory impairment in the aged common marmoset (Callithrix jacchus)

Frontiers in Aging Neuroscience, 2023
Morphology and function of the dorsolateral prefrontal cortex (dlPFC), and corresponding working memory performance, are affected early in the aging process, but nearly half of aged individuals are spared of working memory deficits.
Courtney Glavis-Bloom, Casey R. Vanderlip, Sammy Weiser Novak, Masaaki Kuwajima, Lyndsey Kirk, Kristen M. Harris, Uri Manor, John H. Reynolds   +7 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Universality in Systems with Power-Law Memory and Fractional Dynamics

, 2017
There are a few different ways to extend regular nonlinear dynamical systems by introducing power-law memory or considering fractional differential/difference equations instead of integer ones.
A Toib, AA Kilbas, AA Kilbas, AA Kilbas, BN Lundstrom, BN Lundstrom, C Pozzorini, D Baleanu, D Matignon, D Mozyrska, D Mozyrska, D Mozyrska, DA Leopold, DC Rubin, F Atici, G-C Wu, G-C Wu, GA Anastassiou, GM Zaslavsky, GSF Frederico, HL Gray, I Petras, I Podlubny, JT Wixted, JT Wixted, JT Wixted, KS Miller, M Edelman, M Edelman, M Edelman, M Edelman, M Edelman, M Rivero, M Wyrwas, MJ Kahana, MS Zilany, N Ulanovsky, NRO Bastos, NRO Bastos, P Cvitanovic, RAC Ferreira, RM May, SG Samko, VE Tarasov, VE Tarasov, VE Tarasov   +45 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Memory circuit elements: from systems to applications

, 2010
In this paper, we briefly review the concept of memory circuit elements, namely memristors, memcapacitors and meminductors, and then discuss some applications by focusing mainly on the first class.
Di Ventra, M., Martinez-Rincon, J., Pershin, Y. V.   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source