Results 61 to 70 of about 2,374,100 (265)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A labeled Clinical-MRI dataset of Nigerian brains
Scientific DataThere is currently a paucity of neuroimaging data from the African continent, limiting the diversity of data from a significant proportion of the global population. This in turn diminishes global health research and innovation.
Eberechi Wogu +15 more
doaj +1 more source
Psicologia: Reflexão e Crítica, 2008 Neste artigo é apresentada uma revisão da literatura sobre o desenvolvimento da memória, organizada de acordo com a divisão dos diferentes armazenamentos ou sistemas existentes. O desenvolvimento das memórias sensorial, de trabalho, explícita e implícita
Maria Paula Carneiro
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
System metric for holographic memory systems [PDF]
Optics Letters, 1996 We introduce M/# as a metric for characterizing holographic memory systems. M/# is the constant of proportionality between diffraction efficiency and the number of holograms squared. Although M/# is a function of many variables in a holographic recording system, it can be measured from the recording and erasure of a single hologram.
F H, Mok, G W, Burr, D, Psaltis
openaire +2 more sources
Off-line processing: reciprocal interactions between declarative and procedural memories [PDF]
The acquisition of declarative (i.e., facts) and procedural (i.e., skills) memories may be supported by independent systems. This same organization may exist, after memory acquisition, when memories are processed off-line during consolidation ...
Brown, Rachel M., Robertson, Edwin M.
core +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
wiley +1 more source
Towards an integration of deep learning and neuroscience
Frontiers in Computational Neuroscience, 2016 Neuroscience has focused on the detailed implementation of computation, studying neural codes, dynamics and circuits. In machine learning, however, artificial neural networks tend to eschew precisely designed codes, dynamics or circuits in favor of brute
Adam Henry Marblestone +2 more
doaj +1 more source
Memory effects in complex materials and nanoscale systems
, 2010 Memory effects are ubiquitous in nature and are particularly relevant at the nanoscale where the dynamical properties of electrons and ions strongly depend on the history of the system, at least within certain time scales.
Di Ventra, Massimiliano +1 more
core +1 more source