Results 131 to 140 of about 61,156 (193)

Utilizing Virtual Clinical Trials to Inform Target Coverage That Drives RSV Antiviral Efficacy

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Respiratory syncytial virus (RSV) infection can result in a range of disease severity from mild upper respiratory tract symptoms to lower respiratory tract illness, with clinical manifestations dependent on age, co‐morbidities, and immune status.
J. Cody Herron, Kathryn G. Link, Natalie Meacham, Negar Niki Alami, Daniel W. Brookes, Elaine Thomas, Jan Adams, Sima S. Toussi, Ryan Franke, Cynthia J. Musante, Isabel Najera, Richard Allen, Britton Boras   +12 more
wiley   +1 more source

Caballeronia Bacteremia in Children with Cancer, United States. [PDF]

Emerg Infect Dis
Glasgow HL, Federico SM, Ribiero RC, Adderson EE.   +3 more
europepmc   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, Volume 183, Issue 15, Page 4344-4363, August 2026.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Integrated drivers of basal and acute immunity in diverse human populations. [PDF]

Cell Rep Med
Hegab Souquette A, Allen EK, Oshansky CM, Rampersaud E, Walker EV, Tang L, Wong SS, Jeevan T, Shi L, Pounds S, Qu JH, Elias G, Kuan G, Balmaseda A, Zapata R, Shaw-Saliba K, Van Damme P, Van Tendeloo V, Dib JC, Crawford JC, Ogunjimi B, Webby R, Schultz-Cherry S, Pekosz A, Rothman RE, Gordon A, Thomas PG.   +26 more
europepmc   +1 more source

Application of Systems Genetics to Investigate Molecular Pathology of Early‐Onset Colorectal Cancer

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Early‐onset colorectal cancer (EOCRC) presents a complex molecular landscape that requires integrated multi‐omics approaches. This article reviews current applications of systems genetics in EOCRC research and provides a step‐by‐step protocol for network‐based analyses featuring PIK3CA to demonstrate practical application for researchers of all levels.
Minjae J. Kim, Sydney L. Carr, Vishnutheertha Kulkarni, Mary‐Louise Manchadi   +3 more
wiley   +1 more source

Pediatric Pulmonary Hypertension: A Systematic Approach. [PDF]

JACC Case Rep
Corson A, Philip R, Tailor N, Chakraborty A, Littleford K, McCormick G, Walsh A.   +6 more
europepmc   +1 more source

Hypothermic Machine Perfusion in Deceased Donor Kidney Transplantation: Provider and Transplant Center Practices and Perspectives

Clinical Transplantation, Volume 40, Issue 8, August 2026.
ABSTRACT Background Hypothermic machine perfusion (HMP), an organ preservation technique used in deceased donor kidney transplantation, improves early outcomes compared to traditional static cold storage while also providing a loosely validated organ viability assessment. Methods We designed a survey to better understand the practices, perceptions, and
Beatrice P. Concepcion, Laura A. Binari, Vasanthi Balaraman, Angie Nishio‐Lucar, Anju Yadav, Ankita Patel, Kenneth J. Woodside, Krista L. Lentine, M. Lee Sanders, Oluwafisayo O. Adebiyi, Sabiha M. Hussain, Shikha Mehta, Vignesh Viswanathan, Xingxing S. Cheng, Ronald F. Parsons   +14 more
wiley   +1 more source

Towards a feature-based regulatory benchmark for user-centred SaMD design in cancer care. [PDF]

BMJ Health Care Inform
Kheirinejad S, Brett CL, Davis RL, Schwartz DL, Shaban-Nejad A.   +4 more
europepmc   +1 more source

Potential of Trichloroacetic Acid in Smear Layer and Calcium Hydroxide Removal in Root Canals-Exploratory Pilot Studies In Vitro. [PDF]

Int Dent J
Munoz E, Benbow AB, Russell JC, Morrow BR, Pannkuk TF, Xin B, Huang GT.   +6 more
europepmc   +1 more source

CYP2C19 c.681G>A Is not in Complete Linkage Disequilibrium With c.332‐23A>G: Implications for Pharmacogenetic Testing

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT CYP2C19 plays an important role in the metabolism of many medications, including the antiplatelet agent clopidogrel, the antifungal agent voriconazole, selective serotonin reuptake inhibitors, select tricyclic antidepressants, and proton pump inhibitors.
Amy J. Turner, Erin C. Boone, Cyrine E. Haidar, Wenjian Yang, Ashley D. Derezinski, Andrew Haddad, Philip E. Empey, Ulrich Broeckel, Andrea Gaedigk   +8 more
wiley   +1 more source