Results 281 to 290 of about 271,662 (318)

Mendelian Randomization

JAMA, 2017
Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may be attributed to our inability to randomize the exposure variable in observational studies. Mendelian randomization (MR) is one approach to overcome confounding.
Connor A, Emdin   +2 more
openaire   +4 more sources

Mendelian Randomization

Cold Spring Harbor Perspectives in Medicine, 2021
Mendelian randomization borrows statistical techniques from economics to allow researchers to analyze the effects of the environment, drug treatments, and other factors on human biology and disease. Taking advantage of the fact that genetic variation is randomized among children from the same parents, it allows genetic variants known to influence ...
openaire   +2 more sources

Colorectal Cancer Risk between Mendelian and Non-Mendelian Inheritance

Clinics in Colon and Rectal Surgery, 2023
AbstractHereditary colorectal cancer has been an area of focus for research and public health practitioners due to our ability to quantify risk and then act based on such results by enrolling patients in surveillance programs. The wide access to genetic testing and whole-genome sequencing has resulted in identifying many low/moderate penetrance genes ...
Elizabeth A, Hibler   +2 more
openaire   +2 more sources

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