Results 301 to 310 of about 236,698 (345)

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. [PDF]

BMC Oral Health
Zhang G, Zheng J, Zhou Y, Zhou M, Zhang J, Liu Y, Geng Y, Wang W, Xin M, Yang B, Zhang L, Huang L.   +11 more
europepmc   +1 more source

Differential Organ Ageing Is Associated With Age‐Related Macular Degeneration

Aging Cell, EarlyView.
Using the UK Biobank, this study trained neural networks to estimate the biological age of individuals according to markers of organ function. Computing the difference between the estimated organ age and chronological age yielded an estimate for accelerated or slowed ageing.
Anastasios Papadam, Arimantas Lionikas, Felix Grassmann   +2 more
wiley   +1 more source

Type 2 diabetes as a risk factor for promoting hypertrophic scar formation after wound healing: a two-sample mendelian randomization study. [PDF]

Arch Dermatol Res
Zheng W, Lai W, Zhang Y, Wang X, Yang K, Zhou X, Chen Z, Yang R, Deng L.   +8 more
europepmc   +1 more source

From Clinical to Benchside: Lacticaseibacillus and Faecalibacterium Are Positively Associated With Muscle Health and Alleviate Age‐Related Muscle Disorder

Aging Cell, EarlyView.
Old people with or without sarcopenia exhibited different gut microbiota and metabolite compositions. Mice receiving microbes from people with sarcopenia displayed lower muscle mass and strength compared with those receiving microbes from non‐sarcopenic donors.
Chaoran Liu, Pui Yan Wong, Nilakshi Barua, Baoqi Li, Hei Yuet Wong, Ning Zhang, Simon Kwoon Ho Chow, Sunny Hei Wong, Jun Yu, Margaret Ip, Wing Hoi Cheung, Gustavo Duque, Christoph Brochhausen, Joseph Jao Yiu Sung, Ronald Man Yeung Wong   +14 more
wiley   +1 more source

A causal association between osteoporosis and postural instability: a Mendelian randomization study. [PDF]

Sci Rep
Zhu K, An Z, Li Y, Zhang Q, Zhang F, Zhao R, Yu H, Yao Q.   +7 more
europepmc   +1 more source

Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians

Aging Cell, EarlyView.
Circulating factors are strongly implicated in modulating biological aging. In this study we show that the serum proteomic and metabolomic profile of high functioning octogenarians suggests lower activation of SASP, preservation of the tryptophan‐kynurenic pathway, higher lipophosphatidyl cholines promoting mitochondrial function, and reduced ...
Ceereena Ubaida‐Mohien, Ruin Moaddel, Sally Spendiff, Norah J. MacMillan, Marie‐Eve Filion, Jose A. Morais, Julián Candia, Liam F. Fitzgerald, Tanja Taivassalo, Paul M. Coen, Luigi Ferrucci, Russell T. Hepple   +11 more
wiley   +1 more source

Smoking and asthma mediate the protective effect of educational attainment on chronic obstructive pulmonary disease risk: a mediation Mendelian randomization analysis. [PDF]

BMC Pulm Med
Bai X, Chen L, Ren F, Zhao Y, Zheng Y, Wang Y, Pang S, Zhang J, Guo E, Li H.   +9 more
europepmc   +1 more source

Causal Analysis Between Gut Microbes, Aging Indicator, and Age‐Related Disease, Involving the Discovery and Validation of Biomarkers

Aging Cell, EarlyView.
A comprehensive causal effect analysis was used to illustrate the associations between gut microbiota, aging indicators, and age‐related diseases. This study provides evidence that supports the association between the gut microbiota and aging and highlights the potential of genetic correlation and causal relationship analysis in biomarker discovery ...
Chunrong Lu, Xiaojun Wang, Xiaochun Chen, Tao Qin, Pengpeng Ye, Jianqun Liu, Shuai Wang, Weifei Luo   +7 more
wiley   +1 more source

Prolonged leisure time television watching as a risk factor for chronic obstructive pulmonary disease: Insights from Mendelian randomization. [PDF]

Medicine (Baltimore)
Li Y, Zhou Q, Cheng Y, Guo L, Yu Y, Jiang M, Deng L, Sun L, Feng X, Zhang Z.   +9 more
europepmc   +1 more source

Identifying PDAP1 as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study

Aging Cell, EarlyView.
Integration of multi‐omics analyses reveals PDAP1 as one of the key regulators of longevity and aging. Mendelian randomization, colocalization, prospective studies, and in vitro experiments highlight PDAP1's effects on mortality, lifespan, and cellular senescence.
Tianzhichao Hou, Zimo Sha, Qi Wang, Yuanyue Zhu, Zheng Zhu, Huajie Dai, Yijie Zhu, Tiange Wang, Mian Li, Zhiyun Zhao, Yu Xu, Jieli Lu, Jie Zheng, Jing Ye, Weiqing Wang, Guang Ning, Yufang Bi, Weiguo Hu, Min Xu   +18 more
wiley   +1 more source