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Depression and sarcopenia: a Mendelian randomization analysis
Psychiatric Genetics, 2023Background The association between depression and sarcopenia has been reported in observational studies but the causality of depression on sarcopenia remained unknown. We aimed to assess the causal effect between major depressive disorder (MDD) and sarcopenia using the two-sample Mendelian randomization (MR) method.
Yehong, Lu, Ruijie, Zhang, Qiang, Zheng
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Two‐Sample Multivariable Mendelian Randomization Analysis Using R
Current Protocols, 2021AbstractMendelian randomization is a framework that uses measured variation in genes for assessing and estimating the causal effect of an exposure on an outcome. Multivariable Mendelian randomization is an extension that can assess the causal effect of multiple exposures on an outcome, and can be advantageous when considering a set (>1) of ...
Danielle, Rasooly, Gina M, Peloso
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On Mendelian randomization analysis of case‐control study
Biometrics, 2019AbstractMendelian randomization (MR) analysis uses genotypes as instruments to estimate the causal effect of an exposure in the presence of unobserved confounders. The existing MR methods focus on the data generated from prospective cohort studies. We develop a procedure for studying binary outcomes under a case‐control design.
Han Zhang +6 more
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A General Approach to Sensitivity Analysis for Mendelian Randomization
Statistics in Biosciences, 2020Mendelian Randomization (MR) represents a class of instrumental variable methods using genetic variants. It has become popular in epidemiological studies to account for the unmeasured confounders when estimating the effect of exposure on outcome. The success of Mendelian Randomization depends on three critical assumptions, which are difficult to verify.
Weiming, Zhang, Debashis, Ghosh
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Obesity and peripheral arterial disease: A Mendelian Randomization analysis
Atherosclerosis, 2016Observational studies showed that obesity is a major risk factor for peripheral arterial disease (PAD). However, conventional epidemiology studies are vulnerable to residual bias from confounding factors. We aimed to explore the causality of obesity in development of PAD using Mendelian Randomization (MR) approach.A MR analysis was performed in 11,477 ...
Ya, Huang +13 more
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Apolipoprotein and peripheral artery disease: Mendelian randomization analysis
VascularBackground The prevalence of peripheral arterial disease (PAD) is on the rise globally, leading to adverse clinical outcomes. Our aim was to investigate the causal relationship between apolipoprotein and PAD, as well as the potential mediating role of smoking, diabetes, hypertension, myocardial infarction, and ischemic stroke.
Chen-Xin Wan, Yu-Shu Gong, Tao Xu
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PM2.5 associates with blood pressure: a Mendelian randomization analysis
International Journal of Environmental Health ResearchThe relationship between fine particulate matter (PM2.5) and blood pressure (BP) is a controversial issue. We conducted a two-sample Mendelian randomization (MR) analysis and identified 58 genome-wide significant single-nucleotide polymorphisms associated with PM2.5 as instrument variables.
Minghui, Bao +3 more
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