Results 41 to 50 of about 18,293 (187)

Leptomeningeal metastasis as a presenting manifestation of adenocarcinoma of the lung: a case report [PDF]

Journal of Research in Clinical Medicine, 2020
Leptomeningeal metastasis (LM) also known as meningeal carcinomatosis is a rare but grave complication seen in the terminal stage of a known primary cancer.
Mazyar Hashemilar, Behrooz Shokouhi, Abolhassan Shakeri Bavil, Elyar Sadeghi-Hokmabadi, Nasrin Forghani   +4 more
doaj   +1 more source

Quantification of Vascular Burden on Cranial Vessel Wall Magnetic Resonance Imaging and Ophthalmic Complications in Giant Cell Arteritis

ACR Open Rheumatology, Volume 8, Issue 5, May 2026.
Objective There is a need for measures of disease severity for giant cell arteritis (GCA), which may enable identification of high‐risk subgroups (eg, ophthalmic complications) and individualized approaches to therapy. We derived a continuous score using data from cranial vessel wall magnetic resonance imaging (VW‐MRI) to quantify vascular burden in ...
David L. Yang, Quy Cao, Fang Liu, Tara McWilliams, Ryan Rebello, Madhura A. Tamhankar, Shubhasree Banerjee, Rui Liang, Robert M. Kurtz, Joshua F. Baker, Naomi Amudala, Zhaoyang Fan, Jae W. Song, Peter A. Merkel, Jeffrey Morris, Rennie L. Rhee   +15 more
wiley   +1 more source

Blindness due to leptomeningeal carcinomatosis as an initial manifestation of recurrent acute lymphoblastic leukemia

Taiwan Journal of Ophthalmology, 2019
Leptomeningeal carcinomatosis (LC) is an uncommon presentation of acute lymphoblastic leukemia (ALL), and it is a devastating and life-threatening complication.
Ya-Chi Huang, Cyuan-Jheng Wang, Jieh-Ren Jou   +2 more
doaj   +1 more source

Patient of carcinoma cervix presenting with oculomotor palsy due to meningeal carcinomatosis- a case report [PDF]

, 2016
We report a case of isolated pupil involving oculomotor nerve palsy as the inaugural and the only clinical sign of meningeal carcinomatosis (MC) in a patient of carcinoma of cervix. There were no other neurological signs and symptoms except for headache.
Kaur, Inderjit, Kaur, Harharpreet, Girgila, Kawalinder   +2 more
core   +1 more source

Therapeutic Strategies to Overcome Payload Resistance of Trastuzumab Deruxtecan in HER2‐Positive Cancers

Cancer Science, Volume 117, Issue 4, Page 996-1009, April 2026.
Overexpression of ABC transporters, especially ABCG2 and ABCB1, mediates acquired resistance to T‐DXd in HER2‐positive cancers. Inhibition of these transporters restored T‐DXd efficacy, highlighting efflux‐mediated resistance as a potential therapeutic target. ABSTRACT Antibody–drug conjugates (ADCs) are emerging as a promising class of targeted cancer
Yuya Murase, Shigeki Nanjo, Sachiko Arai, Sota Kondo, Hayato Koba, Yifeng Liu, Koji Fukuda, Shigeki Sato, Jun Kinoshita, Noriyuki Inaki, Tsukasa Ueda, Shunichi Nomura, Yuichi Tambo, Takahiro Shimizu, Masafumi Horie, Daichi Maeda, Richard W. Wong, Kazuyoshi Hosomichi, Takafumi Kobayashi, Satoshi Watanabe, Kenta Yamamura, Noriyuki Ohkura, Miki Abo, Seiji Yano   +23 more
wiley   +1 more source

Bilateral Vocal Cord Paralysis Following Influenza A: Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Flexible nasal endoscopy demonstrating bilateral vocal cord paralysis (BVCP) in the paramedian position. The left image demonstrates a glottic gap between the vocal cords (white arrows) in the maximally adducted position (patient saying “eeee”). Under normal circumstances the vocal cords should be touching with no glottic gap. The right image shows his
Dan H. V. Tran, Xiang Lay, Winston Cheung, Blake Lindsay, Benjamin Worrall, Sarika Suresh, Arun Aggarwal, Mark Kol, Atul Wagh, Rosalba Cross, Asim Shah   +10 more
wiley   +1 more source

Rapid symptomatic relief of HER2-positive gastric cancer leptomeningeal carcinomatosis with lapatinib, trastuzumab and capecitabine: a case report

BMC Cancer, 2018
Background Gastric cancer patients with widespread metastasis, especially meningeal metastases, have an extremely prognosis and limited therapeutic choices.
Xiao-Dong Jiao, Chunming Ding, Yuan-Sheng Zang, Guanzhen Yu   +3 more
doaj   +1 more source

Carcinomatous meningitis in non-small cell lung cancer: Palliation with intrathecal treatment

Indian Journal of Medical and Paediatric Oncology, 2014
Carcinomatous meningitis or meningeal carcinomatosis is seen in up to 5% of patients of metastatic non-small cell lung cancer. However, isolated carcinomatous meningitis without brain parenchymal metastasis is less common.
D. Santhosh Kumar, Vanita Noronha, Amit Joshi, Hasmukh Jain, Kumar Prabhash   +4 more
doaj   +1 more source

Multiple Cranial Neuropathies After Lenvatinib–Pembrolizumab Therapy for Metastatic Renal Cell Carcinoma: A Case Report

IJU Case Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Introduction Multiple cranial neuropathy is a rare manifestation of immune‐related adverse events. To date, no cases have been reported during immune checkpoint blockade for metastatic renal cell carcinoma. This report describes a case of multiple cranial neuropathy that developed during lenvatinib and pembrolizumab combination therapy.
Hideyuki Minagawa, Tomoyuki Kaneko, Keiichi Hokkoku, Ayano Miyashima, Inoue Hazuki, Ono Tenei, Risako Yagi, Kenjiro Kishitani, Kazuki Takei, Tohru Nakagawa   +9 more
wiley   +1 more source

Patients with chronic post‐dural puncture headache do not have typical imaging features of intracranial hypotension: An MRI study using the Bern score

Headache: The Journal of Head and Face Pain, Volume 66, Issue 1, Page 193-201, January 2026.
Abstract Objective This study evaluated cranial magnetic resonance imaging (MRI) signs in patients with post‐dural puncture headache (PDPH) using an established assessment score developed for spontaneous intracranial hypotension (Bern score). We hypothesize that patients with chronic PDPH do not have typical imaging features of intracranial hypotension.
Charlotte Zander, Christian Fung, Amir El Rahal, Florian Volz, Katharina Wolf, Alexander Rau, Hansjörg Mast, Jürgen Beck, Horst Urbach, Niklas Lützen   +9 more
wiley   +1 more source