Results 41 to 50 of about 43,022 (268)

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

open access: yesAdvanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li   +9 more
wiley   +1 more source

Unresectable Recurrent Multiple Meningioma: A Case Report with Radiological Response to Somatostatin Analogues

open access: yesCase Reports in Oncology, 2016
Medical treatment of meningiomas is reserved for cases in which surgery and radiotherapy have failed. Given that a high percentage of meningiomas express somatostatin receptors, treatment with somatostatin analogues has been proposed.
Ana Ortolá Buigues   +3 more
doaj   +1 more source

Salmonella meningitis a rare presentation in adult [PDF]

open access: yes, 2016
Salmonella is a leading cause of food-borne infections worldwide. There are more than 2500 different serovars of salmonella enterica found to date, causing primarily gastroenteritis.
latif, Anum   +2 more
core   +1 more source

Observations at the CNS–PNS Border of Ventral Roots Connected to a Neuroma [PDF]

open access: yes, 2010
Previous studies have shown that numerous sprouts originating from a neuroma, after nerve injury in neonatal animals, can invade spinal nerve roots. In this study the border between the central and peripheral nervous system (CNS-PNS border) of ventral ...
Sten Remahl   +4 more
core   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

open access: yesAdvanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng   +13 more
wiley   +1 more source

Meningeal Hemangiopericytoma with Intracranial Metastases in an HIV-Positive Male: Case Report and Review of the Literature

open access: yesCase Reports in Oncology, 2012
Background: Meningeal hemangiopericytoma is a rare, aggressive CNS tumor that tends to invade locally, metastasize, and has a high rate of recurrence.
Zachary Beatty, Thomas Bergman
doaj   +1 more source

Neurosarcoidose: orientações para o neurologista geral [PDF]

open access: yes, 2012
Neurosarcoidosis (NS) more commonly occurs in the setting of systemic disease. The diagnosis is based on a clinical history suggestive of NS, presence of noncaseating granulomas, and supportive evidence of sarcoid pathology, laboratory, and imaging ...
Abrahão, Agessandro   +5 more
core   +2 more sources

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li   +13 more
wiley   +1 more source

A rare case of breast carcinoma metastasis into a meningioma in a 64-year-old female patient

open access: yesRadiology Case Reports
This report discusses the occurrence of tumor-to-tumor metastasis—an atypical phenomenon in oncology where a secondary malignancy develops within an existing primary tumor.
Edwin Mogere, MBChB, MMed   +5 more
doaj   +1 more source

Mast cells in central nervous system neoplasms: an immunohistochemical study

open access: yesRevista Mexicana de Neurociencia, 2023
Objective: To investigate the relationship between mast cells (MCs) and different central nervous system (CNS) tumors. Methods: It was a comparative immunohistochemical study to investigate the presence, number, and location of MCs in pilocytic ...
Aldair Ochoa-Rojas   +6 more
doaj   +1 more source

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