Results 121 to 130 of about 122,319 (302)
Epistemological Anatomy: A Conceptual Framework for Understanding Anatomical Knowledge
Clinical Anatomy, EarlyView.ABSTRACT Anatomy is often regarded as settled knowledge. Yet anatomical propositions differ enormously in their evidentiary foundations, while textbooks and atlases frequently present them with similar certainty. How, then, does an anatomical observation become anatomical knowledge? We introduce epistemological anatomy as a framework for the systematic
Marios Loukas +5 more
wiley +1 more source
The Curious History of the External Petrosal Nerve: Did Citations Replace Observations?
Clinical Anatomy, EarlyView.ABSTRACT Anatomical knowledge is founded on repeated observation, independent verification, and transmission through authoritative texts. Although this process typically strengthens scientific understanding, transmission through textbooks may occasionally perpetuate observations that have not undergone sustained empirical confirmation.
Joel A. Vilensky +3 more
wiley +1 more source
Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning
Cytoskeleton, EarlyView.ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham +3 more
wiley +1 more source
Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset
Clinical Pharmacology &Therapeutics, EarlyView.Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit +6 more
wiley +1 more source
Extravascular trypanosomes appear in the meninges.
, 2015 A. GFP trypanosomes in the meninges at 32 dpi. Blue: collagen. Faint magenta: blood marker (Qdots). B. At the level of vertical penetrating vessels and parenchymal capillaries, intravascular trypanosomes were detected (arrow), but extravascular ...
Elmarie Myburgh (379323) +7 more
core +1 more source
Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley +1 more source
Epileptic Disorders, EarlyView.Abstract Background Triphasic waves (TWs), now termed generalized periodic discharges with triphasic morphology, may be mistaken for nonconvulsive status epilepticus (NCSE), particularly in critically ill patients. Changes in vigilance over time can help distinguish encephalopathic patterns from ictal activity.
Philippe Gélisse, Arielle Crespel
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective To assess the feasibility, technical performance, and safety of a novel endovascular electroencephalogram (eEEG) electrode, EP‐01, designed for minimally invasive seizure localization in patients with drug‐resistant epilepsy. Methods This single‐center, prospective, exploratory trial enrolled five patients with drug‐resistant ...
Kota Araki +9 more
wiley +1 more source