Results 181 to 190 of about 122,319 (302)

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source

Aging brain lesions of a 60-year-old Bornean orangutan (Pongo pygmaeus). [PDF]

J Vet Med Sci
Nakayama Y, Chambers JK, Ota K, Yamaguchi A, Toda K, Sato S, Kato A, Kamakura Y, Uchida K.   +8 more
europepmc   +1 more source

Equine vegetative endocarditis and vertebral osteomyelitis due to refractory Erysipelothrix rhusiopathiae infection

Equine Veterinary Education, EarlyView.
Summary Erysipelothrix rhusiopathiae was the causative agent of vegetative endocarditis and vertebral osteomyelitis in a 24‐year‐old Irish draught gelding that presented with prolonged history of intermittent pyrexia and tachycardia. Clinical investigations revealed persistently reduced neck mobility, tachydysrhythmia and episodic pyrexia up to 41°C ...
E. Kolovou, Z. Daobry, Â. J. F. Mendes, G. Weller, S. Radhakrishnan, M. S. I. Sajib, M. Fuentes, F. Zendri, T. Forde, W. Weir, J. Del‐Pozo, D. G. M. Sutton   +11 more
wiley   +1 more source

Mechanisms of Neural Stem Cell Mediated Neurogenesis and Therapeutic Prospects Following Ischemic Stroke: A Review. [PDF]

Stem Cells Int
Wang S, Zhang J, Wang P, Ye P, Wu J, Shi L, Jiang X, Lu Y, Ge H, Yu A.   +9 more
europepmc   +1 more source

Enhancement of the leptomeninges in a young man

Brain Pathology, EarlyView.
Jayden Ray, Mohammad Alberawi, Andrew Bauer, Kar‐Ming Fung, Erika Santos Horta, Lorraina J. Robinson   +5 more
wiley   +1 more source

Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

The FEBS Journal, EarlyView.
Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester, Owen Leitzel, Samantha Golf, Chelsea M. Phillips, Michael J. Zeitz, Rahul Pandit, Elizabeth Wash, Jenna V. Donohue, Elizabeth A. Istre, James W. Smyth, Samy Lamouille, Stefanie Robel   +11 more
wiley   +1 more source

First Case Report of a Dog With Intracranial Granular Cell Tumor Treated With Stereotactic Radiotherapy. [PDF]

Vet Radiol Ultrasound
Murakami K, Rancilio NJ, Harm TA, Nenninger AS, Hollman SE.   +4 more
europepmc   +1 more source

SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC‐derived model

The FEBS Journal, EarlyView.
In this study, we characterised the role of SHIP1 in regulating TREM2 signalling and global microglial myeloid functions using human‐induced pluripotent stem cell (hiPSC)‐derived macrophages. Knockout of SHIP1 (SHIP1 KO) in macrophages decreased inflammatory activation and levels of scavenger receptors. SHIP1 KO macrophages also exhibited reduced TREM2
Kim S. Martin, Juliane Obst, Shania Ibarra, Emma J. Murphy, Katerina O. Gospodinova, Emma Mead   +5 more
wiley   +1 more source

Plasma amylin levels in migraine and after erenumab treatment: A REFORM study

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary Researchers are searching for blood tests that can show what is happening in migraine and help predict who will benefit from preventive treatment, and blood amylin (a signaling molecule known to trigger migraine) has been shown to be elevated in people with chronic migraine.
Rogelio Domínguez‐Moreno, Tyla I. Alexander, William K. Karlsson, Haidar M. Al‐Khazali, Michael L. Garelja, Rune H. Christensen, Messoud Ashina, Debbie L. Hay, Håkan Ashina   +8 more
wiley   +1 more source

DNA methylation profiling identifies long-range epigenetic silencing of clustered protocadherins as a key determinant of meningioma progression. [PDF]

Nat Commun
Merk DJ, Paßlack P, Surender S, Tsiami F, Haeusser LA, Arnold V, Sampath-Kumar V, Sevenich L, Maier AD, Mathiesen T, Tatagiba M, Gött H, Tellermann J, Behling F, Schittenhelm J, Becker H, Tabatabai G.   +16 more
europepmc   +1 more source