Results 11 to 20 of about 103,286 (345)

Lactylation-Driven PROS1-TYRO3-CARF Signaling Promotes Therapy-Induced Senescence Escape and Radioresistance in Meningioma. [PDF]

Adv Sci (Weinh)
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Wang Z, Zhang Q, Liao K, Liu X, Zhang H, Chen Y, Ma Y, Liu Y, Xu A, Sun Y, Chen J, Bian L, Wang B.   +12 more
europepmc   +2 more sources

Xanthomatous meningioma; a rare histological variant [PDF]

The Medical Journal of Basrah University, 2018
Introduction: Meningiomas are tumors of the central nervous system originating from the meningothelial tissues, the arachnoid cap cells of the cranium and spinal cord.
Jasim Al-Diab, Hasan Almohammed, Sura Al-Namil   +2 more
doaj   +1 more source

A molecularly integrated grade for meningioma

Neuro-Oncology, 2021
Background Meningiomas are the most common primary intracranial tumor in adults. Clinical care is currently guided by the World Health Organization (WHO) grade assigned to meningiomas, a 3-tiered grading system based on histopathology features, as well ...
Joseph Driver, Samantha E. Hoffman, S. Tavakol, Eleanor L. Woodward, Eduardo A. Maury, Varun M. Bhave, Noah F. Greenwald, F. Nassiri, K. Aldape, G. Zadeh, A. Choudhury, H. Vasudevan, S. Magill, D. Raleigh, Malak S. Abedalthagafi, A. Aizer, B. Alexander, K. Ligon, D. Reardon, P. Wen, O. Al-Mefty, A. Ligon, A. Dubuc, R. Beroukhim, Elizabeth B. Claus, I. Dunn, S. Santagata, W. Bi   +27 more
semanticscholar   +1 more source

External validation and recalibration of an incidental meningioma prognostic model - IMPACT: Protocol for an international multicentre retrospective cohort study [PDF]

, 2022
Introduction Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an estimated prevalence of 3 ...
Brodbelt, Andrew R, Millward, CP, Mills, SJ, Mathew, Ryan K, Jakola, Asgeir Store,, Kolamunnage-Dona, Ruwanthi, Georgious, T, Mathew, RK, Fountain, DM, Fountain, Daniel M, Santarius, Thomas, Santarius, T, Jenkinson, Michael D, Koszdin, SD, IMPACT Study Investigators, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC),, Kolamunnage-Dona, R, Piper, Rory J, Mehta, Shaveta, Koszdin, Shelli Diane, Ali, U, Islim, AI, Islim, Abdurrahman I, Millward, Christopher P, Näslund, Olivia,, Mehta, S, Ali, Usama, Brodbelt, AR, Georgious, Theo, Jenkinson, MD, Piper, RJ, Mills, Samantha J   +30 more
core   +4 more sources

Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response

Genome Medicine, 2022
Background Recent investigations of the meninges have highlighted the importance of the dura layer in central nervous system immune surveillance beyond a purely structural role. However, our understanding of the meninges largely stems from the use of pre-
Anthony Z. Wang, Jay A. Bowman-Kirigin, Rupen Desai, L. Kang, Pujan R. Patel, B. Patel, Saad M. Khan, D. Bender, M. C. Marlin, Jingxian Liu, J. Osbun, E. Leuthardt, M. Chicoine, Ralph G. Jr Dacey, G. Zipfel, A. Kim, D. DeNardo, A. Petti, G. Dunn   +18 more
semanticscholar   +1 more source

Spinal Clear Cell Meningioma: Atypical Clinical and Radiological Manifestations

Case Reports in Surgery, 2021
Meningioma has many subtypes with clear cell meningioma being more aggressive than other variants of meningioma and one of the rarest. We report a case of spinal clear cell meningioma that occurred in a 25-year-old lady who presented with the inability ...
Mohammad Nasser Alsadiq, Zainab Shaker Albarbari, Fatimah Alshakhs, Muath Ali Alduayji, Shaymaa Al-Umran, Abdulrahman Alenzi   +5 more
doaj   +1 more source

Pitfalls in the Histopathologic Diagnosis of Meningioma: Report of Three Rare Variants of Meningioma and Literature Review

Case Reports in Clinical Practice, 2021
Meningioma is a common primary tumor of the central nervous system and one of the most encountered brain tumors. Although classic histopathologic features of meningioma are relatively common and make its diagnosis straightforward, certain variants ...
Ghazaleh Shaker, Farid Azmoudeh Ardalan, Mehdi Zeinalizadeh   +2 more
doaj   +1 more source

Emerging systemic treatment options in meningioma

Journal of Neuro-Oncology, 2022
Purpose Meningiomas are the most frequently diagnosed intracranial neoplasms. Usually, they are treated by surgical resection in curative intent. Radiotherapy and stereotactic radiosurgery are commonly applied in the adjuvant setting in newly diagnosed ...
M. Mair, A. Berghoff, P. Brastianos, M. Preusser   +3 more
semanticscholar   +1 more source

Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study

British medical journal, 2021
Objective To assess the risk of meningioma associated with use of high dose cyproterone acetate, a progestogen indicated for clinical hyperandrogenism. Design Observational cohort study.
A. Weill, P. Nguyen, M. Labidi, Benjamin Cadier, T. Passeri, L. Duranteau, A. Bernat, Isabelle Yoldjian, Sylvie Fontanel, S. Froelich, J. Coste   +10 more
semanticscholar   +1 more source

Meningioma: not always a benign tumor. A review of advances in the treatment of meningiomas

CNS Oncology, 2021
Meningiomas are the most common primary intracranial tumors. The majority of meningiomas are benign, but they can present different grades of dedifferentiation from grade I to grade III (anaplastic/malignant) that are associated with different outcomes ...
I. Maggio, E. Franceschi, A. Tosoni, V. di Nunno, Lidia Gatto, R. Lodi, A. Brandes   +6 more
semanticscholar   +1 more source