Results 61 to 70 of about 45,550 (255)

KMT2C Loss Promotes NF2‐Wildtype Meningioma Progression and Ferroptosis Sensitivity via Epigenetic Repression of Hippo Signaling

open access: yesAdvanced Science, EarlyView.
In NF2–wild‐type meningiomas, loss of the epigenetic regulator KMT2C suppresses NF2 transcription and inactivates Hippo signaling, driving tumor progression and increasing ferroptosis sensitivity. Restoration of histone acetylation reverses these effects and inhibits tumor growth, identifying KMT2C as a key regulator linking epigenetic control, NF2 ...
Liuchao Zhang   +13 more
wiley   +1 more source

Balancing small against large burdens [PDF]

open access: yes, 2018
Common principles for resource allocation in health care can prioritize the alleviation of small health burdens over lifesaving treatment. I argue that there is some evidence that these principles are at odds with a sizable share of public opinion, which
Voorhoeve, Alex
core   +3 more sources

A Hybrid Transfer Learning Framework for Brain Tumor Diagnosis

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
A novel hybrid transfer learning approach for brain tumor classification achieves 99.47% accuracy using magnetic resonance imaging (MRI) images. By combining image preprocessing, ensemble deep learning, and explainable artificial intelligence (XAI) techniques like gradient‐weighted class activation mapping and SHapley Additive exPlanations (SHAP), the ...
Sadia Islam Tonni   +11 more
wiley   +1 more source

Diagnóstico e conduta cirúrgica nos meningiomas de tubérculo selar

open access: yesBrazilian Neurosurgery, 2007
Os meningiomas do tubérculo selar, juntamente com os da goteira olfatória, estão entre os tumores mais freqüentes da fossa craniana anterior. Os sintomas característicos são déficits visuais, distúrbios do comportamento, crises epilépticas, anosmia e ...
Tobias Alécio Mattei   +4 more
doaj   +1 more source

Meningiomas occurring during long-term survival after treatment for childhood cancer

open access: yes, 2014
Childhood cancer is rare but improvements in treatment over the past five decades have resulted in a cohort of more than 30,000 long-term survivors of childhood cancer in the UK with more added annually.
Bhangoo, R.   +4 more
core   +1 more source

KDLM: Lightweight Brain Tumor Segmentation via Knowledge Distillation

open access: yesAdvanced Intelligent Systems, EarlyView.
A lightweight student network is designed, which is based on multiscale and multilevel feature fusion and combined with the residual channel attention mechanism to achieve efficient feature extraction and fusion with very few parameters. A dual‐teacher collaborative knowledge distillation framework is proposed.
Baotian Li   +4 more
wiley   +1 more source

Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations [PDF]

open access: yes, 2014
Meningiomas are the most common primary nervous system tumor. The tumor suppressor NF2 is disrupted in approximately half of meningiomas1 but the complete spectrum of genetic changes remains undefined.
Beroukhim, Rameen   +17 more
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay   +5 more
wiley   +1 more source

Epidemiology and survival of non-malignant and malignant meningiomas in middle-aged females, 2004-2018

open access: yesFrontiers in Oncology, 2023
BackgroundThe incidence of meningioma is disparate to sex: meningiomas are more common in women than in men, especially in middle-aged women. Understanding the epidemiology and survival of middle-aged women with meningiomas would help estimate their ...
Junguo Cao   +5 more
doaj   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

open access: yesChemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

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