Results 41 to 50 of about 14,805 (180)

Complement Factor H‐Based Therapeutics: A Comprehensive Overview

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H‐based therapeutic concepts and modalities to treat complement‐mediated diseases.
Sebastiaan M. W. R. Hamers, Emmy J. Buter, Richard B. Pouw   +2 more
wiley   +1 more source

"Bacterial Meningitis in children and adolescents: an observational study based on the national surveillance system"

BMC Infectious Diseases, 2005
Background Bacterial meningitis is a group of life threatening infections that mostly affect children and adolescents, and may be the cause of severe neurological sequelae.
Dickinson Félix O, Pérez Antonio E
doaj   +1 more source

A Case Report on Meningitis Complicated by Acute Ischemic Stroke and Failed Thrombolysis

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Ischemic stroke is one of the rare but grave complications of meningitis with poor outcomes and long‐term sequelae, and the role of thrombolysis with infection‐related stroke remains uncertain. This case report documents a 52‐year‐old man presented with fever, headache, vomiting, and altered sensorium, and on examination he had neck rigidity ...
Sonam Dema, Dechen Choden, Sonam Wangmo
wiley   +1 more source

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ‐, tissue‐, or cell‐specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and ...
Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw   +2 more
wiley   +1 more source

Haemophilus influenzae serotype a meningitis in an elderly patient: A case report and literature review

IDCases
Haemophilus influenzae is a gram-negative bacterium that encompasses a diverse group of strains with varying pathogenic potentials. Classified into six serotypes (a-f), it has been historically associated with a range of infections, including respiratory
Harika Kalangi, Anjali Anne Ajit, Bernard Camins, Stanley R. Yancovitz   +3 more
doaj   +1 more source

Epidemiology of infectious meningitis in the State of Amazonas, Brazil

Revista da Sociedade Brasileira de Medicina Tropical, 2015
INTRODUCTION: In the State of Amazonas, particularly in the capital Manaus, meningitis has affected populations of different cultures and social strata over the years.
Maria das Graças Gomes Saraiva, Eyde Cristianne Saraiva Santos, Valéria Saraceni, Lívia Laura dos Santos Rocha, Rossicléia Lins Monte, Bernardino Cláudio de Albuquerque, Michele de Souza Bastos, Marcelo Cordeiro dos Santos, Wuelton Marcelo Monteiro, Maria Paula Gomes Mourão, Marcus Vinitius de Farias Guerra, Marcus Vinícius Guimarães de Lacerda   +11 more
doaj   +1 more source

Lung Microbiome Diversity, Infection Dynamics, and Microbe‐Mediated Cross‐Protection

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The protective role of the lung microbiome in maintaining respiratory health by promoting immune homeostasis, pathogen exclusion, and barrier integrity. Diverse microbial communities regulate immune maturation, enhance epithelial defenses, and contribute to antiviral responses, collectively preventing pathogen colonization and sustaining a balanced ...
Sana Arooj, Akmal Zubair, Syeda Zaira Batool, Granaz Niaz, Muhammad Ali, Yasir Waheed, Eman Ramadan Elsharkawy, Naila Afghan   +7 more
wiley   +1 more source

A novel case of autosomal recessive CARD11 loss‐of‐function underlying impaired antiviral immunity and a review of literature

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
We report on a patient homozygous for a novel autosomal recessive loss‐of‐function CARD11 variant, with susceptibility to live attenuated virus (LAV) vaccines and impaired clearance of multiple naturally acquired respiratory viral infections. Inborn errors of immunity affecting the CARD11‐BCL10‐MALT1 (CBM) complex should be considered in individuals ...
Hamish Anderson, Cecilia Verryt, Paula Keating, Thomas Saunders, Samuel Dalton, Barry D Hock, Liping Goddard, Kylie Drake, Anja Werno, John O'Donnell, Jeffrey R Stinson, Andrew L Snow, Kuang‐Chih Hsiao   +12 more
wiley   +1 more source

Childhood meningitis in Kuwait in the era of post pneumococcal conjugate vaccination: A multicenter study

Journal of Infection and Public Health, 2017
This is a retrospective study to evaluate epidemiology and etiologies of childhood meningitis in Kuwait after the routine introduction of the pneumococcal conjugate vaccine. The data was collected from 196 patients in the period of 2010–2014.
Hussain Sadeq, Entesar H. Husain, Amna Alkoot, Suha Atyani, Abdullah Al-fraij, Abdulrahman Al-Daithan, Talal AlSaleem, Anfal Taher, May Alenezi   +8 more
doaj   +1 more source

The Epidemiology of Sickle Cell Disease in Sub‐Saharan Africa: Current Knowledge and Gaps to be Filled

American Journal of Hematology, Volume 101, Issue S1, Page 5-16, April 2026.
What are the available data on incidence & prevalence prognosis risk factors of severity of sickle cell disease in sub‐Saharan Africa? ABSTRACT Sickle Cell Disease (SCD) is highly prevalent in sub‐Saharan Africa. Epidemiological data remain sparse, but regional screening and research initiatives are expanding.
Brigitte Ranque, Leon Tshilolo, Thomas N. Williams   +2 more
wiley   +1 more source