Results 71 to 80 of about 3,300,287 (280)

Tocilizumab provides a potential therapeutic option for the management of hyperhaemolysis syndrome in sickle cell disease: A case series and brief narrative overview of the literature

open access: yesTransfusion Medicine, EarlyView.
Abstract Background and Objectives Hyperhaemolysis syndrome is a life‐threatening complication of transfusion, potentially triggered by macrophage activation, with limited treatment options. Tocilizumab, an anti‐IL6 monoclonal antibody, has mechanistic rationale for use and has been shown to be effective in a small number of cases.
S. Wolf   +8 more
wiley   +1 more source

Māori and community news constructions of Meningococcal B: the promotion of a moral obligation to vaccinate [PDF]

open access: yes, 2007
News media communicate various risks of disease, showcase medical breakthroughs and disseminate texts that both reflect and renegotiate shared cultural understandings of health and illness. Little is known about the role of Māori and community news media
Chamberlain, Kerry   +5 more
core   +2 more sources

Application of Causal Inference to Establish Assay Effect in the Absence of a Bridging Study: A Case Study of MenACWY‐CRM Conjugate Vaccine Data

open access: yesPharmaceutical Statistics, Volume 25, Issue 2, March/April 2026.
ABSTRACT During a vaccine development program, if the assay used to measure immunological endpoints is changed, ideally, a bridging study is performed to establish the relationship between results obtained with the new and previous assay. However, this is not always feasible, and when bridging study data are absent, this can limit the ability to use ...
Meike Adani   +4 more
wiley   +1 more source

Iowa Health Focus, September 2004 [PDF]

open access: yes, 2004
Monthly newsletter for the Iowa Department of Public ...

core  

Assessment of acute headache in adults - what the general physician needs to know. [PDF]

open access: yes, 2018
Headache is common. Up to 5% of attendances to emergency departments and acute medical units are due to headache. Headache is classified as either primary (eg migraine, cluster headache) or secondary to another cause (eg meningitis, subarachnoid ...
Agrawal   +9 more
core   +1 more source

Economic Burden of Sickle Cell Disease: A Retrospective Study of Pediatric and Adult Individuals With Medicaid Coverage From 2016 to 2020

open access: yesAmerican Journal of Hematology, Volume 101, Issue 2, Page 269-280, February 2026.
ABSTRACT There is limited information regarding the contemporary real‐world clinical and financial burden of Medicaid enrollees with sickle cell disease (SCD) in the United States. Using the IBM MarketScan Medicaid database (7/2016–12/2020), individuals with ≥ 3 SCD diagnoses were matched 1:1 on age, gender, and race to individuals without SCD ...
Giovanna Tedesco Barcelos   +4 more
wiley   +1 more source

Systemic meningococcal disease in children: survival analysis, Arkhangelsk region, Northwest Russia, 1991–2011

open access: yesЖурнал инфектологии, 2014
Systemic meningococcal infection requires prompt and adequate medical care. It is considered as unpredictable disease due to extreme severity of a patient’s condition and high risk for fatal outcome.
O. V. Samodova   +4 more
doaj   +1 more source

Evidence for Multi-Organ Infection During Experimental Meningococcal Sepsis due to ST-11 Isolates in Human Transferrin-Transgenic Mice

open access: yesMicroorganisms, 2020
The description of invasive meningococcal disease that is provoked by Neisseria meningitidis (Nm) is frequently restricted to meningitis. However, a wide panel of clinical presentations can be encountered including severe forms with intense inflammatory ...
Michael Levy   +2 more
doaj   +1 more source

Iptacopan for Immune Thrombocytopenia and Cold Agglutinin Disease: A Global Phase 2 Basket Clinical Trial

open access: yesAmerican Journal of Hematology, Volume 101, Issue 2, Page 242-254, February 2026.
ABSTRACT Iptacopan is a first‐in‐class, oral, selective inhibitor of complement factor B that has demonstrated positive efficacy across several complement‐driven diseases. Here we evaluate the efficacy and safety of iptacopan monotherapy in adult patients with primary immune thrombocytopenia (ITP) and primary cold agglutinin disease (CAD). We performed
Alexander Röth   +13 more
wiley   +1 more source

Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis

open access: yesmBio, 2018
Pediatric meningococcal sepsis often results in morbidity and/or death, especially in young children. Our understanding of the reasons why young children are more susceptible to both the meningococcal infection itself and a more fulminant course of the ...
Noortje de Haan   +7 more
doaj   +1 more source

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