Results 51 to 60 of about 30,178 (272)

Confirmation of Fixed Quarterly Riliprubart Regimen in Patients with Cold Agglutinin Disease Using Population PK/PD and Exposure‐Response Analyses

Clinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 449-458, August 2025.
Riliprubart is a second‐generation, humanized immunoglobulin G4 that inhibits only the activated form of the C1s component of the proximal classical complement pathway. The clinical studies of riliprubart conducted thus far for the treatment of cold agglutinin disease (CAD), a rare autoimmune disease, include a Phase 1 first‐in‐human study in healthy ...
Timothy Chow, Marek Wardecki, Michael Storek, Nancy Wong   +3 more
wiley   +1 more source

Bacterial outer membrane vesicles and vaccine applications [PDF]

, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo, Acosta, Armando, Campa, Concepcion, Cardoso, Daniel, Fernandez, Sonsire, Ferro, Valerie, Garcia, Luis, Perez, Jose Luis, Rosenqvist, Einar, Sarmiento, Maria Elena, Zayas, Caridad   +10 more
core   +2 more sources

A Vaccine Against Group B Streptococcus: Recent Advances [PDF]

, 2020
Group B streptococcus (GBS) causes a high burden of neonatal and infant disease globally. Implementing a vaccine for pregnant women is a promising strategy to prevent neonatal and infant GBS disease and has been identified as a priority by the World ...
Carreras-Abad, C, Heath, PT, Le Doare, K, Ramkhelawon, L   +3 more
core   +2 more sources

Herpesviruses, as a possible cause complicated course of invasive meningococcal disease (clinical case)

Журнал инфектологии, 2016
The article describes the clinical case of meningococcal infections, complicated with the development of reactive arthritis. It highlights possible pathogenetic mechanisms of aseptic inflammation in combined meningococcal and herpesvirus infections.
N. V. Skripchenko, A. A. Vilnits, A. S. Drap, I. A. Ivashchenko   +3 more
doaj  

Neisseria meningitidis Sequence Type and Risk for Death, Iceland

Emerging Infectious Diseases, 2006
Invasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004.
Magnús Gottfreðsson, Mathew A. Diggle, David I. Lawrie, Helga Erlendsdóttir, Hjördís Harðardóttir, Karl G. Kristinsson, Stuart C. Clarke   +6 more
doaj   +1 more source

Increased incidence of Neisseria meningitidis infections in Nuevo León, Mexico

Salud Pública de México, 2020
[Not available]
María Teresa Ramírez-Elizondo, Elvira Garza-González, Gabriela Echániz-Aviles, Samantha Flores-Treviño, María Noemí Carnalla-Barajas, Adrián Camacho-Ortiz   +5 more
doaj   +1 more source

Safety, Efficacy, and Patient‐Reported Outcomes From a Phase 2 Randomized Trial of Pozelimab and Cemdisiran Combination in Patients With Paroxysmal Nocturnal Hemoglobinuria

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra‐rare, life‐threatening disease associated with chronic intravascular hemolysis due to uncontrolled complement activation. PNH results in anemia with an increased risk of thrombosis, and often causes severe fatigue, and decreased physical function and health‐related quality of ...
Jun‐Ho Jang, Raymond Siu Ming Wong, Christopher Hartford, Rodrigo Pavani, Lisa Aurand, Quang Nguyen, Kosalai Mohan, Karoline Meagher, Steven Sherman, Diana Rofail, Lorah Perlee, Amal Souttou, Richard J. Kelly   +12 more
wiley   +1 more source

Fatal meningococcal meningitis in a HIV-infected patient caused by serogroup C Neisseria meningitidis belonging to the non-hypervirulent clonal complex ST-60 (cc60)

Brazilian Journal of Infectious Diseases, 2011
Meningococcal strains belonging to clonal complex cc60 are not associated with hypervirulent lineages and were never reported as causing disease in Latin American countries.
Claudia Ferreira de Andrade, Biologist, Denise Cotrim da Cunha, MD, Veronica Cavalcanti, Biologist, Ivano de Filippis   +3 more
doaj  

The effect of sleep and shift work on the primary immune response to messenger RNA‐based COVID‐19 vaccination

Journal of Sleep Research, Volume 34, Issue 4, August 2025.
Summary Shift work can cause circadian misalignment, which often results in sleeping problems and has been associated with immune dysfunction. To better understand the impact of shift work on a primary immune response to vaccination, we compared severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)‐specific humoral and cellular immune responses ...
Tamara M. J. Brouwers, Ümmü Gülsüm Çobanoğlu, Daryl Geers, Wim J. R. Rietdijk, Lennert Gommers, Susanne Bogers, Gert Jan Lammers, Gijsbertus T. J. van der Horst, Inês Chaves, Corine H. GeurtsvanKessel, Birgit C. P. Koch, Rory D. de Vries, Debbie van Baarle, Hugo M. van der Kuy, Heidi M. Lammers‐van der Holst   +14 more
wiley   +1 more source

Meningococcal vaccine. From capsular polysaccharides of microbes to proteases

RUDN Journal of Medicine, 2012
Microbial capsular polysaccharides for many years provided a highly practical public health vaccines for preventing meningococcal, pneumococcal and Haemophilus influenza infection, and typhoid fever.
A P Alliluyev, I V Anokhina, L D Rumsh, E E Melnikov, O V Kotelnikova, E A Sitnikova, E J Drozzina, L S Zhigis, E J Yagudayeva, O A Razgulyaeva, V S Zueva, L V Kozlov, A E Avakov   +12 more
doaj