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Vaccines against Meningococcal Diseases [PDF]
Neisseria meningitidis is the main cause of meningitis and sepsis, potentially life-threatening conditions. Thanks to advancements in vaccine development, vaccines are now available for five out of six meningococcal disease-causing serogroups (A, B, C, W,
Mariagrazia Pizza+2 more
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Clonal analysis of meningococci during a 26 year period prior to the introduction of meningococcal serogroup C vaccines [PDF]
Meningococcal disease remains a public health burden in the UK and elsewhere. Invasive Neisseria meningitidis, isolated in Scotland between 1972 and 1998, were characterised retrospectively to examine the serogroup and clonal structure of the circulating
Clarke, Stuart C.+3 more
core +23 more sources
Meningococcal disease is one of the most feared and serious infections in the young and its prevention by vaccination is an important goal. The high degree of antigenic variability of the organism makes the meningococcus a challenging target for vaccine prevention. Meningococcal polysaccharide vaccines against serogroup A and C are efficacious and have
Rüggeberg, J, Pollard, A
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Meningococcal vaccines in China [PDF]
Meningococcal meningitis caused by Neisseria meningitidis is a reportable infectious disease in China, due to the high incidence of meningitis in the era before the availability of vaccines. The disease incidence was markedly reduced after meningococcal vaccination was introduced in the 1980s.
Shanshan Wang+5 more
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Meningococcal Vaccinations [PDF]
Neisseria meningitidis, a gram-negative diplococcal bacterium, is a common asymptomatic nasopharyngeal colonizer that may infrequently lead to invasive disease in the form of meningitis or bacteremia. Six serogroups (A, B, C, W, X and Y) are responsible for the majority of invasive infections.
Eva Sullivan, Nancy F. Crum-Cianflone
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Meningococcal Vaccine Trials [PDF]
The evaluation of meningococcal vaccines in humans is a challenging task. Issues of safety, and benefit to the individual patient and to the community may raise difficult ethical problems. The inherent variability of human responses, the rarity of clinical disease, age-dependence in the immune response, and the role of carriers complicates the ...
Paddy Farrington, Elizabeth Miller
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The successful introduction of a protein-polysaccharide conjugate vaccine against serogroup C meningococci into the UK infant immunization schedule, in combination with a catch-up campaign for individuals less than 18 years of age, has seen virtually all group C disease eliminated in childhood.
Bethell, D, Pollard, A
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Meningococcal glycoconjugate vaccines [PDF]
Neisseria meningitidis is a major cause of invasive bacterial infections worldwide. For this reason, efforts to control the disease have been directed at optimizing meningococcal vaccines and implementing appropriate vaccination policies. In the past, plain polysaccharide vaccines containing purified capsular polysaccharides A, C, Y and W135 were ...
GASPARINI, ROBERTO, PANATTO, DONATELLA
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Meningococcal vaccination in pregnancy [PDF]
Invasive meningococcal disease causes meningitis and septicemia worldwide with highest rates of disease occurring in children
Manish Sadarangani+2 more
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