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Meningococcal Vaccines and Vaccine Developments
2003Despite rapid advances in the diagnosis of bacterial infections and the availability of effective antibiotics, meningococcal disease continues to represent a substantial public health problem for most countries (1-4). Disease usually develops rapidly, is notoriously difficult to distinguish from other febrile illnesses, and generally has a high case ...
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Meningococcal protein antigens and vaccines
Vaccine, 2009The development of a comprehensive vaccine against meningococcal disease has been challenging. Recent developments in molecular genetics have provided both explanations for these challenges and possible solutions. Since genome sequence data became available there has been a marked increase in number of protein antigens that have been suggested as ...
Mariagrazia Pizza, Ian M. Feavers
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Meningococcal tetravalent conjugate vaccine
Expert Opinion on Biological Therapy, 2008Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. Since 1981, a tetravalent meningococcal polysaccharide vaccine has been available in the US but it has been limited to high-risk patients and outbreak settings. In 2005, a tetravalent polysaccharide meningococcal conjugate vaccine (MCV4) was licensed for routine use in the US.
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Development of meningococcal vaccines
1978A few years after the discovery of Meningococcus by Weichselbaum in 18871 numerous vaccines were described and tested almost everywhere in the world. Davis2 seems to have been the first to attempt active immunization, in 1907, using meningococcal cultures heated to 60 °C.
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Meningococcal Disease and Vaccines
Pediatric Annals, 2001Peter M. Dull, Nancy E. Rosenstein
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Meningococcal disease in Asia: an under-recognized public health burden
Epidemiology and Infection, 2011Guining Lu
exaly