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The Future of Meningococcal Vaccines
Pediatric Infectious Disease Journal, 2005Despite antibiotics and supportive care ~10% of persons with meningococcal infection die 9-19% have sequelae (skin grafting amputation hearing deficits) and outbreaks often provoke panic. Meningococcal meningitis is the main cause of bacterial meningitis in children in the United States.
Carol J. Baker, C. Mary Healy
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Meningococcal conjugate vaccines
Expert Opinion on Biological Therapy, 2005Disease caused by Neisseria meningitidis is associated with high mortality rates and significant sequelae. Polysaccharide meningococcal vaccines have been available for > 20 years, and have been used in travellers to control outbreaks, and in some countries for adolescents entering college, although they provide only a short duration of immunity and do
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Expert Review of Vaccines, 2018
Introduction: Given the characteristics of meningococcal carriage and transmission and the sudden, often severe onset and long-term consequences of disease, vaccination can most effectively provide large-scale control of invasive disease. Six serogroups (
John L. Perez +12 more
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Introduction: Given the characteristics of meningococcal carriage and transmission and the sudden, often severe onset and long-term consequences of disease, vaccination can most effectively provide large-scale control of invasive disease. Six serogroups (
John L. Perez +12 more
semanticscholar +1 more source
Meningococcal vaccine in travelers
Current Opinion in Infectious Diseases, 2007New vaccines to prevent meningococcal disease have been licensed in recent years. It is therefore timely to discuss current vaccine strategies pertinent to international travelers in relation to the changing epidemiology.Serogroup W135 achieved epidemic status in Africa in 2002, and then largely disappeared over a short time period. The year 2006 saw a
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A half-century of meningococcal vaccines
Vaccine, 2021The first safe and effective vaccine for the prevention of invasive meningococcal disease was created fifty years ago. The vaccine employed a novel platform, polysaccharide capsular antigen, based on the discovery that anticapsular antibody conferred protective immunity in humans.
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Meningococcal Vaccines and Vaccine Developments
2003Despite rapid advances in the diagnosis of bacterial infections and the availability of effective antibiotics, meningococcal disease continues to represent a substantial public health problem for most countries (1-4). Disease usually develops rapidly, is notoriously difficult to distinguish from other febrile illnesses, and generally has a high case ...
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The Future of Meningococcal Vaccines
Pediatric Health, 2007The use of vaccines in the prevention of meningococcal disease has demonstrated their success in improving public health globally. Group C conjugate vaccines have significantly reduced the burden of disease in countries with widespread usage. Promising results are available on the candidate group A conjugate vaccine for Africa, which could potentially ...
Paul Balmer, Ray Borrow
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Meningococcal tetravalent conjugate vaccine
Expert Opinion on Biological Therapy, 2008Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. Since 1981, a tetravalent meningococcal polysaccharide vaccine has been available in the US but it has been limited to high-risk patients and outbreak settings. In 2005, a tetravalent polysaccharide meningococcal conjugate vaccine (MCV4) was licensed for routine use in the US.
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Development of meningococcal vaccines
1978A few years after the discovery of Meningococcus by Weichselbaum in 18871 numerous vaccines were described and tested almost everywhere in the world. Davis2 seems to have been the first to attempt active immunization, in 1907, using meningococcal cultures heated to 60 °C.
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