Results 81 to 90 of about 590,194 (288)

Modeling COVID-19 vaccine-induced immunological memory development and its links to antibody level and infectiousness [PDF]

arXiv, 2022
COVID-19 vaccines have proven to be effective against SARS-CoV-2 infection. However, the dynamics of vaccine-induced immunological memory development and neutralizing antibodies generation are not fully understood, limiting vaccine development and vaccination regimen determination. Herein, we constructed a mathematical model to characterize the vaccine-
arxiv  

Escherichia coli in the production of biopharmaceuticals

Biotechnology and Applied Biochemistry, Volume 72, Issue 2, Page 528-541, April 2025.
Abstract Escherichia coli has shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, in E. coli and its use in treating diabetes. After insulin, many biopharmaceuticals produced from E. coli have been approved by the
İbrahim İncir, Özlem Kaplan
wiley   +1 more source

The Impact of Vaccine Hesitancy on Epidemic Spreading [PDF]

arXiv, 2021
The COVID-19 pandemic has devastated the world in an unprecedented way, causing enormous loss of life. Time and again, public health authorities have urged people to become vaccinated to protect themselves and mitigate the spread of the disease. However, vaccine hesitancy has stalled vaccination levels in the United States.
arxiv  

Hydrocephalus and Cerebral Small Vessel Disease in an Adult With Meningococcal Meningitis and Dilated Cardiomyopathy: A Fatal Outcome

Clinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT Meningococcal meningitis can lead to serious neurological complications such as hydrocephalus directly and contribute to cerebral small vessel disease indirectly, especially in patients with pre‐existing conditions like dilated cardiomyopathy.
Yousif Mohamed, Ahmed Mohamed, Abubaker Elemam, Abubaker Babiker   +3 more
wiley   +1 more source

Detecting Anti-Vaccine Users on Twitter [PDF]

arXiv, 2021
Vaccine hesitancy, which has recently been driven by online narratives, significantly degrades the efficacy of vaccination strategies, such as those for COVID-19. Despite broad agreement in the medical community about the safety and efficacy of available vaccines, a large number of social media users continue to be inundated with false information ...
arxiv  

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study

Clinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Avner Sandhu, Tong Shen, Paz Martin Herrero, Chao‐Xing Yuan, Samirah Qureshi, Xiaoyu Jiang, Ye Sheng, Christoph Gasteyger, Yang Dai   +8 more
wiley   +1 more source

Impact of COVID-19 pandemic on vaccination against meningococcal C infection in Brazil

Vaccine: X, 2022
Objective: Analyzing the impact of COVID-19 pandemic on meningococcal C conjugate vaccination in Brazil. Methods: Ecological study, based on interrupted time series, carried out with data collected through the Information System of the National ...
Thales Philipe Rodrigues da Silva, Leyla Gabriela Verner Amaral Brandão, Ed Wilson Rodrigues Vieira, Thalita Beatriz Santos Maciel, Tércia Moreira Ribeiro da Silva, Bianca Maria Oliveira Luvisaro, Fabiana Ramos de Menezes, Fernanda Penido Matozinhos   +7 more
doaj  

Enter B and W: two new meningococcal vaccine programmes launched

Archives of Disease in Childhood, 2015
In 2015, the UK became the first country in the world to have a comprehensive routine meningococcal vaccine programme targeting all of the main capsular groups of N. meningitidis.
S. Ladhani, M. Ramsay, R. Borrow, A. Riordan, J. Watson, A. Pollard   +5 more
semanticscholar   +1 more source

Long‐Term Efficacy and Safety of Ravulizumab in Adults With Anti‐Acetylcholine Receptor Antibody‐Positive Generalized Myasthenia Gravis: Final Results From the Phase 3 CHAMPION MG Open‐Label Extension

European Journal of Neurology, Volume 32, Issue 4, April 2025.
Ravulizumab demonstrated clinically meaningful and durable efficacy and safety in adults with anti‐acetylcholine receptor antibody‐positive generalized myasthenia gravis in the CHAMPION MG open‐label extension (OLE) study. Improvements from baseline in MG‐ADL, QMG, and MG‐QOL15r total scores, and the NeuroQOL Fatigue subscale scores achieved in ...
Tuan H. Vu, Renato Mantegazza, Djillali Annane, Masahisa Katsuno, Andreas Meisel, Michael W. Nicolle, Vera Bril, Rasha Aguzzi, Glen Frick, James F. Howard Jr, the CHAMPION MG Study Group   +10 more
wiley   +1 more source

Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT): A review of the evidence and expert opinion

Expert Review of Vaccines, 2023
Introduction Serogroups A, B, C, W, X, and Y of Neisseria meningitidis are responsible for almost all cases of invasive meningococcal disease. In Italy, vaccination against serogroup B is recommended at 3–13 months, C at 13–15 months, and A, C, Y and W ...
Silvia Ricci, Chiara Azzari, Emanuele Amodio, Paolo Castiglia   +3 more
doaj   +1 more source