Results 61 to 70 of about 14,145 (218)
Clinical Case Reports, Volume 13, Issue 4, April 2025.ABSTRACT Meningococcal meningitis can lead to serious neurological complications such as hydrocephalus directly and contribute to cerebral small vessel disease indirectly, especially in patients with pre‐existing conditions like dilated cardiomyopathy.
Yousif Mohamed +3 more
wiley +1 more source
Meningococcal vaccines in Canada: An update [PDF]
Paediatrics & Child Health, 2011 Meningococcal infection is serious, often resulting in fulminant sepsis or meningitis. There are two main types of meningococcal conjugate vaccine currently available in Canada: serotype C meningococcal conjugate, and quadrivalent conjugate for serotypes A, C, Y, and W-135. The immunological characteristics that inform ongoing immunization policies, as
MI Salvadori, R Bortolussi
openaire +3 more sources
Position statement on the management of pregnancy in sickle cell disease
Australian and New Zealand Journal of Obstetrics and Gynaecology, Volume 65, Issue 2, Page 183-189, April 2025.Sickle cell disease (SCD) is a hereditary haemoglobinopathy which causes multi‐organ dysfunction. Pregnancies in SCD are high risk with significant maternal and fetal morbidity and mortality, including vaso‐occlusive crises, thrombosis, anaemia, placental insufficiency, fetal growth restriction, preterm birth and medication effects. High level evidence
Mimi Yue +5 more
wiley +1 more source
Clinical and Translational Science, Volume 18, Issue 4, April 2025.ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Avner Sandhu +8 more
wiley +1 more source
Meningococcal disease: changes in epidemiology and prevention
Clinical Epidemiology, 2012 Qiuzhi Chang,1 Yih-Ling Tzeng,2 David S Stephens1–31Department of Epidemiology, Rollins School of Public Health, Emory University, 2Department of Medicine, Emory University School of Medicine, 3Laboratories of Microbial Pathogenesis, Department
Chang Q, Tzeng YL, Stephens DS
doaj
European Journal of Neurology, Volume 32, Issue 4, April 2025.Ravulizumab demonstrated clinically meaningful and durable efficacy and safety in adults with anti‐acetylcholine receptor antibody‐positive generalized myasthenia gravis in the CHAMPION MG open‐label extension (OLE) study. Improvements from baseline in MG‐ADL, QMG, and MG‐QOL15r total scores, and the NeuroQOL Fatigue subscale scores achieved in ...
Tuan H. Vu +10 more
wiley +1 more source
Two New Kindreds with Complete Factor D Deficiency
European Journal of Immunology, Volume 55, Issue 3, March 2025.The complement system plays a crucial role in immune defense, and factor D deficiency is a rare immunodeficiency associated with life‐threatening bacterial infections. We report two new cases of complete factor D deficiency, including the first described in a Down syndrome patient, highlighting the need to investigate complement deficiencies in ...
Mathilde Puel +10 more
wiley +1 more source
Public policy for meningococcal vaccination [PDF]
Human Vaccines & Immunotherapeutics, 2018 On an individual basis, meningococcal disease is consistently shown to be one of the most feared potential childhood infections. On a population level, any clustering of cases or increase in disease requires proactive health protection management, while epidemics can be devastating.
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EPIDEMIOLOGY AND PREVENTION OF MENINGOCOCCAL DISEASE: A CRITICAL APPRAISAL OF VACCINE POLICIES
Педиатрическая фармакология, 2012 Meningococcal disease is characterized by a marked variation in incidence and serogroup distribution by region and over time. In several European countries, Canada and Australia, immunization programs, including universal vaccination of infants or ...
Marco AP Safadi, E David G Mcintosh
doaj +1 more source
Prevalence of de-O-acetylated serogroup C meningococci before the introduction of meningococcal serogroup C conjugate vaccines in the United Kingdom [PDF]
, 2000 Ray Borrow +3 more
openalex +2 more sources