Results 61 to 70 of about 10,578 (267)

Mechanical and histological properties of native medial menisci compared to allograph medial menisci in the osteoarthritic knee

Frontiers in Bioengineering and Biotechnology
This study was designed to provide information on how the menisci change over the course of osteoarthritis, particularly with regard to their mechanical properties.
Max Weiske, Bianca Riedel, Eva Johanna Kubosch, Hermann O. Mayr, Hagen Schmal, Michael Seidenstuecker, Michael Seidenstuecker   +6 more
doaj   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Do Not Hallow until You Are out of the Wood! Ultrasonographic Detection of CPP Crystal Deposits in Menisci: Facts and Pitfalls

The Scientific World Journal, 2013
Purpose. Ultrasonography (US) has been demonstrated to be an important tool in the diagnosis of calcium pyrophosphate (CPP) crystal deposition disease.
Georgios Filippou, Antonella Adinolfi, Panagiotis Bozios, Sauro Lorenzini, Valentina Picerno, Valentina Di Sabatino, Ilaria Bertoldi, Dario Gambera, Mauro Galeazzi, Bruno Frediani   +9 more
doaj   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

The Impact of Aging on Meniscal Tears and Chondral Lesions in Men: Insights from First-Time Arthroscopic Knee Evaluation

Life
(1) Background: This is the first study investigating the age-related distribution of meniscal and chondral lesions in an all-male cohort undergoing first-time knee arthroscopy.
Sorin Florescu, Cristian Zaharia, George Andrei Drăghici, Dragoş Vasile Nica, Cosmin Grațian Damian   +4 more
doaj   +1 more source

Evaluation of Histological Properties of Human Meniscal Grafts Stored in a Tissue Bank [PDF]

Revista Brasileira de Ortopedia
Objectives The present paper aims to evaluate and compare the histological features of fresh and frozen menisci stored in a tissue bank for 1 month and for 5 years. Methods The meniscal grafts were subjected to a histological study.
Alfredo dos Santos Netto, Uri Antebi, Carolina Esteves de Morais, Leonardo Sementilli, Nilson Roberto Severino, Ricardo de Paula Leite Cury   +5 more
doaj   +4 more sources

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Prevalence, Development, and Factors Associated with Cyst Formation after Meniscal Repair with the All-Inside Suture Device

Orthopaedic Journal of Sports Medicine, 2020
Aims and Objectives: The aim of this study is to investigate the prevalence of cyst formation as a complication of all-inside meniscal suture device using magnetic resonance imaging (MRI) and analyze the risk factors.
Thore Zantop MD, PD, Yusuke Hashimoto MD, Prof., Hiroaki Nakamura MD, Prof.   +2 more
doaj   +1 more source

Interface‐Directed High Fluorescence Efficiency Two‐Dimensional Molecular Crystals With Surface‐Exposed Active Sites

Advanced Science, EarlyView.
Here, we designed the Me‐FBSe molecule and prepared a two‐dimensional molecular crystal via liquid‐liquid interface assembly. The crystal preserves the high photoluminescence quantum while simultaneously ensuring the high‐density surface exposure of active sites.
Shuya Liu, Yueqiang Zhang, Chuanqin Cheng, Jin Wang, Feiyong Chen, Yonglei Wang, Yanjun Gong   +6 more
wiley   +1 more source

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source