Results 71 to 80 of about 10,578 (267)

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Cryopreservation versus fresh frozen meniscal allograft: A biomechanical comparative analysis

Journal of Orthopaedic Surgery, 2017
Meniscal allograft transplantation may be a better alternative for the treatment of irreparable meniscal injury compared to other forms of treatment.
Shukur Ahmad, Vivek Ajit Singh, Shamsul Iskandar Hussein   +2 more
doaj   +1 more source

Medial and lateral discoid menisci: a case report

Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology, 2010
Discoid menisci on both medial and lateral tibial plateau are very rare abnormalities. We report a 44-year-old woman with bilateral medial and lateral discoid menisci.
Kim Sung-Jae, Lubis Andri MT
doaj   +1 more source

Hamaker Constants of van der Waals Materials under Clean‐Interface Conditions

Advanced Science, EarlyView.
Clean‐interface adhesion in representative van der Waals materials is quantified by Ultra High Vacuum (UHV) Atomic Force Microscopy (AFM) with in situ cleaning and calibrated probes. Benchmark Hamaker constants for graphene, MoS2, and SiO2 are established, while humidity is shown to reversibly amplify adhesion, explaining much of the scatter in ...
Daniel Gallego‐Fuente, Jaime Colchero, Julio Gomez‐Herrero, Pablo Ares   +3 more
wiley   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Somatotopic features of the collagen skeleton of the knee meniscus in men

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Relevance. The structural features of the collagen skeleton, including constitutional ones, suggest the ability of the menisci to withstand excessive mechanical stress and injury.Purpose – to study the differences in the collagen skeleton of the knee ...
A. N. Russkikh, A. D. Shabokha, V. I. Kasimov, B. I. Yaremin   +3 more
doaj   +1 more source

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

Advanced Science, EarlyView.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li, Yingjie Yu, Tianchang He, Xiaoyan Fang, Wenhua Yang, Luying Zhou, Hao Fan, Guimei Lin, Daniel Crespy, Katharina Landfester, Junfeng Zhang, Shuai Jiang   +11 more
wiley   +1 more source

Anatomical study: comparing the human, sheep and pig knee meniscus

Journal of Experimental Orthopaedics, 2016
Background Animal models are commonly used in investigating new treatment options for knee joint injuries including injuries to the meniscus. The reliability and applicability of these models to replicate findings in humans depends on determining the ...
Talal Takroni, Leila Laouar, Adetola Adesida, Janet A. W. Elliott, Nadr M. Jomha   +4 more
doaj   +1 more source

Improved Direct Ink Writing of Liquid Metal Foams via Liquid Additives

Advanced Electronic Materials, EarlyView.
The ability to pattern liquid metal is useful for making soft electrical and thermal devices. Dispensing liquid metal from a nozzle naturally results in the formation of spheroidal droplets, making direct‐write printing challenging. Liquid metal foams containing pockets of air can extrude as filaments, albeit inconsistently.
Febby Krisnadi, Tushar Sakorikar, Man Hou Vong, Michael D. Dickey   +3 more
wiley   +1 more source

Collagen Expression in Various Degenerative Meniscal Changes: An Immunohistological Study

Journal of Orthopaedic Surgery, 2013
Purpose. To examine changes in acid mucopolysaccharides and collagen expression during meniscal degeneration, tearing, and repair, using menisci excised from knee joint surgeries. Methods.
Takatomo Mine, Koichiro Ihara, Hiroyuki Kawamura, Ryo Date, Keitaro Umehara   +4 more
doaj   +1 more source