Results 11 to 20 of about 1,423 (153)

Dauricine Overcomes Osimertinib Resistance in Lung Cancer by Inducing Ferroptosis via Stabilizing SAT1. [PDF]

Cancer Sci
Our study explores the potential of dauricine, a bioactive compound from Menispermum dauricum, to overcome osimertinib resistance in lung cancer. We demonstrate that dauricine, when combined with osimertinib, induces ferroptosis in resistant lung cancer cells by stabilizing SAT1, a key enzyme in oxidative stress regulation.
Men B, Chen Z, Ge H, Yang Z, Yun L, Jiang J, Dian M, He Y, Zhou Z, Zhang R, Yan T, Li Z, Zhang Y, He Y, He J, Rao X, Rao S.   +16 more
europepmc   +2 more sources

Exploration of the Components and Pharmacological Mechanisms of Keyin Pill-Induced Liver Injury Based on Network Pharmacology. [PDF]

Evid Based Complement Alternat Med, 2022
Background. Keyin pill (KP), a patented medicine in China, is used to treat psoriasis. However, KP has been reported to have liver toxicity, but its toxic substance basis and underlying mechanisms remain unclear. Therefore, this study aimed to explore the pharmacological mechanisms and components of KP‐induced liver injury through animal experiments ...
Xing B, Cui Y, Chen Y, Lai L, Zhang M, Xu X, Wang N, Jiang X, Xu Z, Zhao Q.   +9 more
europepmc   +2 more sources

Lineage-Specific CYP80 Expansion and Benzylisoquinoline Alkaloid Diversity in Early-Diverging Eudicots. [PDF]

Adv Sci (Weinh)
Herein, a chromosome‐level genome assembly of Menispermum dauricum is presented. A novel MdCYP80G10 enzyme is identified to catalyze C2′‐C4a phenol coupling of (S)‐reticuline into sinoacutine, the enantiomer of morphinan compounds, with predictable stereospecificity.
An Z, Gao R, Chen S, Tian Y, Li Q, Tian L, Zhang W, Kong L, Zheng B, Hao L, Xin T, Yao H, Wang Y, Song W, Hua X, Liu C, Song J, Fan H, Sun W, Chen S, Xu Z.   +20 more
europepmc   +2 more sources

In the nectar, there are answers: exploring the intersection of colored nectars and reactive oxygen species in manipulating pollinator behavior. [PDF]

New Phytol
Summary Nectar, a vital mediator of plant–pollinator interactions, exhibits remarkable chemical diversity beyond sugars, including reactive oxygen species and specialized metabolites such as pigments. Colored nectars, present in over 70 species, function as visual signals, inhibitors of microbial growth, or nutritional rewards, underscoring their ...
Magner ET, Roy R, Hegeman AD, Carter CJ.
europepmc   +2 more sources

Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014-2023). [PDF]

Chem Biodivers
This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Sipoloni VM, Bassicheto MC, de Oliveira MV, de Souza ABDS, Alves GM, Veiga TAM.   +5 more
europepmc   +2 more sources

Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea

Food Science &Nutrition, Volume 11, Issue 10, Page 5837-5855, October 2023., 2023
This review systematically summarizes the relationship among intestinal flora, chronic diarrhea, and polysaccharides as well as recent progress on the impacts of Chinese herb polysaccharides on the gut microbiota and recent advances on the possible role of CHP in chronic diarrhea.
Hong Xue, Chun‐Feng Mei, Feng‐Yun Wang, Xu‐Dong Tang   +3 more
wiley   +1 more source

Trajectories and state changes of a grassland stream and riparian zone after a decade of woody vegetation removal

Ecological Applications, Volume 33, Issue 4, June 2023., 2023
Abstract Riparian zones and the streams they border provide vital habitat for organisms, water quality protection, and other important ecosystem services. These areas are under pressure from local (land use/land cover change) to global (climate change) processes. Woody vegetation is expanding in grassland riparian zones worldwide.
Walter K. Dodds, Zak Ratajczak, Rachel M. Keen, Jesse B. Nippert, Bartosz Grudzinski, Allison Veach, Jeffery H. Taylor, Amanda Kuhl   +7 more
wiley   +1 more source

Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels

Cardiovascular Therapeutics, Volume 2022, Issue 1, 2022., 2022
Antiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating the function of ion channels. However, several adverse effects and high recurrence rates after drug withdrawal seriously affect patients’ medication compliance and clinical prognosis. Thus, safer and more effective drugs are urgently needed.
Jinshan He, Sicong Li, Yumeng Ding, Yujia Tong, Xuebin Li, Simona Saponara   +5 more
wiley   +1 more source

Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Alzheimer’s disease (AD) is a common neurodegenerative brain disorder that causes cellular response alterations, such as impaired cholinergic mechanism, amyloid‐beta (Aβ) AD aggregation, neuroinflammation, and several other pathways. AD is still the most prevalent form of dementia and affects many individuals across the globe.
Fahadul Islam, Jannatul Fardous Khadija, Md. Harun-Or-Rashid, Md. Saidur Rahaman, Mohamed H. Nafady, Md. Rezaul Islam, Aklima Akter, Talha Bin Emran, Polrat Wilairatana, Mohammad S. Mubarak, Sachchida Nand Rai   +10 more
wiley   +1 more source

Network Pharmacology and Molecular Docking‐Based Strategy to Investigate the Multitarget Mechanisms of Shenqi Yizhi Granule on Alzheimer’s Disease

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Background. Traditional Chinese herbal medicine draws more attention to explore an effective therapeutic strategy for Alzheimer’s disease (AD). Shenqi Yizhi granule (SQYG), a Chinese herbal recipe, has been applied to ameliorate cognitive impairment in mild‐to‐moderate AD patients. However, the overall molecular mechanism of SQYG in treating AD has not
Linshuang Wang, Xiaoyu Xu, Zikang Wang, Qian Chen, Xiaodie Wei, Jingfan Xue, Zhanjun Zhang, Miao Wang, Yanping Li, Junying Zhang, Dongfeng Wei, Weidong Pan   +11 more
wiley   +1 more source