Results 51 to 60 of about 94,546 (247)

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

New trends in current menopausal hormone therapy

Гинекология, 2021
The article presents the results of recent studies on the effectiveness, safety and duration of menopausal hormone therapy (MHT). The main cardio-metabolic risk factors for cardiovascular diseases are formed in women precisely during the transition to ...
Vera E. Balan, Elena V. Tikhomirova, Anastasia S. Zhuravel, Julia P. Titchenko, Tatyana V. Lovygina   +4 more
doaj   +1 more source

Hormonal replacement therapy, prothrombotic mutations and the risk of venous thrombosis [PDF]

, 2002
Hormone replacement therapy (HRT) increases the risk of venous thrombosis. We investigated whether this risk is affected by carriership of hereditary prothrombotic abnormalities.
A. Rumley, Anderson, Bloemenkamp, Daly, E. Daly, F. M. Helmerhorst, F. R. Rosendaal, G. D. O. Lowe, Grady, Grodstein, Hulley, Jick, Kniffin, Lowe, M. Vessey, M. Woodward, Mehta, Nordström, Oger, Rees, Rosendaal, Rosendaal, Silverstein, Stadel, Vandenbroucke, Vessey, Woolf   +26 more
core   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Menopausal symptoms and utilization of menopausal hormone therapy among women aged 40–60 years in Addis Ababa, Ethiopia: a cross-sectional study

BMC Women's Health
Background The onset of menopause leads to diminished estrogen exposure, resulting in a high morbidity burden related to menopausal symptoms. Menopausal hormonal therapy is an effective therapy that offers more advantages than disadvantages for women ...
Tewodros Getahun Asfaw, Rahel Demissew Gebreyohannes, Milcah Temesgen Tesfaye   +2 more
doaj   +1 more source

Climacteric Lowers Plasma Levels of Platelet-Derived Microparticles: A Pilot Study in Pre-versus Postmenopausal Women [PDF]

, 2012
Background: Climacteric increases the risk of thrombotic events by alteration of plasmatic coagulation. Up to now, less is known about changes in platelet-(PMP) and endothelial cell-derived microparticles (EMP). Methods: In this prospective study, plasma
Andreas Rank, Bal L, Berckmans RJ, Berckmans RJ, Bettina Toth, Biro E, Corada M, Cramer EM, Dratva J, Erhard Hiller, Faddy MJ, Flaumenhaft R, Gemmell CH, Giansante C, Gilbert GE, Horstman LL, Joop K, Katharina Nikolajek, Koga H, Kuriyama N, Li X, Miyazaki Y, Myers DD, Nagata Y, Nieuwland R, Nomura S, Rabe T, Ramacciotti E, Rank A, Rank A, Rectenwald JE, Rienk Nieuwland, Sabine Roesner, Sagripanti A, Simak J, Sims PJ, Stevens RF, Tan KT, Tarantino MD, Thiagarajan P, Toth B, Travlos GS, van der Zee PM, Warren BA   +43 more
core   +3 more sources

Alternatives of menopausal hormone therapy

Medicinski pregled, 2016
Introduction. It has been generally accepted that the benefits of menopausal hormone therapy outweigh the risks, but there are still some concerns about the administration of menopausal hormone therapy, which has introduced alternative treatments. Pharmacological Alternatives.
Ranko M, Kutlesic, Jasmina, Popovic, Milan, Stefanovic, Predrag, Vukomanovic, Bojan, Lukic, Goran, Lilic   +5 more
openaire   +3 more sources

Lifetime estrogen exposure and domain-specific cognitive performance: results from the IGNITE study

Frontiers in Aging Neuroscience
IntroductionDisruptions in estrogen exposure (i.e., surgically induced menopause) have been linked to poorer cognitive aging and dementia risk. Hormone therapy use (e.g., birth control, menopausal hormone therapy) has shown mixed associations with ...
Amber Watts, Amber Watts, Shannon Donofry, Shannon Donofry, Hayley Ripperger, Nicole M. Eklund, Lu Wan, Chaeryon Kang, George Grove, Lauren E. Oberlin, Lauren E. Oberlin, Swathi Gujral, Eric D. Vidoni, Jeffrey M. Burns, Edward McAuley, Edward McAuley, Charles H. Hillman, Arthur F. Kramer, Arthur F. Kramer, M. Ilyas Kamboh, Kirk I. Erickson, Kirk I. Erickson   +21 more
doaj   +1 more source

Development of di(2‐ethylhexyl) phthalate‐containing thioglycolic acid immobilized chitosan mucoadhesive gel as an alternative hormone therapy for menopausal syndrome

Bioengineering & Translational Medicine, 2022
Menopausal syndrome includes the symptoms that most women experience owing to hormone changes after menopause. Although hormone replacement therapy is a common treatment for menopausal syndrome, there are still many side effects and challenges hindering ...
I‐Hsuan Yang, I‐En Lin, Ya‐Jyun Liang, Jhih‐Ni Lin, Tzu‐Chien Chen, Zhi‐Yu Chen, Che‐Yung Kuan, Chih‐Ying Chi, Chi‐Han Li, Hung‐Ming Wu, Feng‐Huei Lin   +10 more
doaj   +1 more source

Increased prevalence of colorectal adenomas in women with breast cancer [PDF]

, 2005
Background: The frequency of colorectal adenomas and carcinomas was investigated in a large cohort of women with breast cancer in comparison with matched controls, since data on the occurrence of second tumors in women with breast cancer is controversial.
Bayerdörffer, Ekkehard, Eiermann, Wolfgang, Göke, Burkhard, Mannes, Gerd Alexander, Meining, Alexander, Ochsenkühn, Thomas, Sackmann, Michael, Späth, Lydia, Wiebecke, Baldur   +8 more
core   +1 more source