Results 131 to 140 of about 777,245 (290)

Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways

open access: yesAdvanced Science, EarlyView.
Chronic social stress elevates oxytocin levels, leading to immunosuppression by enhancing regulatory T‐cell activity and promoting anti‐inflammatory macrophage polarization in the spleen. Blocking oxytocin signaling reverses these effects but worsens stress‐induced behavioral disorders and reduces survival rates. This highlights oxytocin's dual role in
Yi‐Shu Zhang   +5 more
wiley   +1 more source

Abnormal resting-state functional connectivity in subregions of amygdala in adults and adolescents with major depressive disorder

open access: yesBMC Psychiatry
Background The different symptoms of major depressive disorder (MDD) in adolescents compared to adults suggested there may be differences in the pathophysiology between adolescents and adults with MDD.
Lin Guan   +10 more
doaj   +1 more source

Knowledge of and attitude towards depression among urban and rural residents in Beijing: a cross-sectional study

open access: yesBMJ Open
Objectives To compare the level of knowledge of depression, recognition ability and attitudes towards depression among urban and rural residents in Beijing.Design A cross-sectional study.Setting Six districts in Beijing, China, 2021.Participants A total ...
Han Qi   +15 more
doaj   +1 more source

MDD-5k: A New Diagnostic Conversation Dataset for Mental Disorders Synthesized via Neuro-Symbolic LLM Agents [PDF]

open access: yesarXiv
The clinical diagnosis of most mental disorders primarily relies on the conversations between psychiatrist and patient. The creation of such diagnostic conversation datasets is promising to boost the AI mental healthcare community. However, directly collecting the conversations in real diagnosis scenarios is near impossible due to stringent privacy and
arxiv  

The Dynamic Landscape of 3′‐UTR Alternative Polyadenylation Across Mouse Fetal Development and Anatomy

open access: yesAdvanced Science, EarlyView.
This work maps 3′‐UTR APA across mouse fetal development and tissues, identifying conserved sequence determinants that influence pAS choice. In fetal brain tissues, complex APA dynamics during development are potentially regulated by RBPs like Rbm38, which restrict distal pAS usage.
Qin Wang, Xin Chen, Xiao‐Ou Zhang
wiley   +1 more source

Efficacy and safety of Neurocognitive Adaptive Training for Depression combined with SSRIs for treating cognitive impairment among patients with late-life depression: a 12-week, randomized controlled study

open access: yesBMC Psychiatry
Background This randomized, open-label study examined the therapeutic effects of Neurocognitive Adaptive Training for Depression (NCAT-D) combined with selective serotonin reuptake inhibitors (SSRIs) on cognitive impairment among patients with late-life ...
Xiao Wang   +9 more
doaj   +1 more source

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