Results 21 to 30 of about 5,076,978 (312)

Peripheral NMDAR subunits as predictors of working memory improvement in schizophrenia

Schizophrenia
Cognitive dysfunction is a defining characteristic impairing social functioning in schizophrenia (SZ). N-methyl-D-aspartate receptor (NMDAR) hypofunction may underlie these impairments.
Xiangqin Qin, Wenpeng Hou, Zhen Mao, Hang Li, Qi Wang, Yushen Ding, Lige Ge, Fuchun Zhou, Qijing Bo, Xianbin Li, Chuanyue Wang, Fang Dong   +11 more
doaj   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder

Translational Psychiatry, 2021
Antidepressants are often the first-line medications prescribed for patients with major depressive disorder (MDD). Given the critical role of the default mode network (DMN) in the physiopathology of MDD, the current study aimed to investigate the effects
Jian Cui, Yun Wang, Rui Liu, Xiongying Chen, Zhifang Zhang, Yuan Feng, Jingjing Zhou, Yuan Zhou, Gang Wang   +8 more
doaj   +1 more source

Sources of Stress and Their Associations With Mental Disorders Among College Students: Results of the World Health Organization World Mental Health Surveys International College Student Initiative

Frontiers in Psychology, 2020
The college years are stressful for many students. Identifying the sources of stress and their relative importance in leading to clinically significant emotional problems may assist in the development of targeted stress management interventions.
E. Karyotaki, P. Cuijpers, Y. Albor, J. Alonso, R. Auerbach, J. Bantjes, R. Bruffaerts, D. Ebert, P. Hasking, G. Kiekens, Sue Lee, M. McLafferty, A. Mak, P. Mortier, N. Sampson, Dan J Stein, G. Vilagut, R. Kessler   +17 more
semanticscholar   +1 more source

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan, Stephanie A. Chu, Suvi Häkkinen, Liwen Zhang, David McFall, Jonathan D. Rohrer, Jesse A. Brown, Alex J. Lee, Kristen Fernhoff, Lorenzo Pasquini, Katherine P. Rankin, Maria Luisa Mandelli, Maria Luisa Gorno‐Tempini, Jennifer S. Yokoyama, Virginia E. Sturm, Brian Appleby, Bradford C. Dickerson, Kimiko Domoto‐Reilly, Tatiana Foroud, Daniel H. Geschwind, Nupur Ghoshal, Neill R. Graff‐Radford, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward Huey, Kejal Kantarci, Irene Litvan, Ian R. Mackenzie, Mario F. Mendez, Chiadi U. Onyike, Leonard Petrucelli, Eliana Marisa Ramos, Erik D. Roberson, Julio C. Rojas, Maria Carmela Tartaglia, Arthur W. Toga, Sandra Weintraub, Leah K. Forsberg, Hilary W. Heuer, Brad F. Boeve, Adam L. Boxer, Howard J. Rosen, Bruce L. Miller, Fermin Moreno, William W. Seeley, Suzee E. Lee, on behalf of the ALLFTD Consortium   +46 more
wiley   +1 more source

Association of hypertension and depression with mortality: an exploratory study with interaction and mediation models

BMC Public Health
Background The association of hypertension and depression with mortality has not been fully understood. We aimed to explore the possible independent or joint association of hypertension and depression with mortality.
Huanhuan Huang, Fanchao Meng, Yanjie Qi, Xiuping Yan, Junhui Qi, Yuanzhen Wu, Yiwei Lin, Xu Chen, Fan He   +8 more
doaj   +1 more source

Risk factors for osteoporosis in chronic schizophrenia on long-term treatment with antipsychotics: a cross-sectional study

BMC Psychiatry, 2023
Background Little is known about the laboratory variable risks with bone mineral density (BMD) in patients with schizophrenia. This study was designed to fully investigate the related risk factors for decreased BMD in schizophrenia, as well as evaluate ...
Furu Liu, Ying Wu, Jindong Chen, Tianxiang Zou, Yue Qin, Ziwei Teng, Yuhan Su, Renrong Wu, Jing Huang   +8 more
doaj   +1 more source

Practice Recommendations for Genetic Testing of Ataxias

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan, Amy D. Mook, Michelle Rochman, Jin Yun Helen Chen, Weiyi Mu, George R. Wilmot, Liana S. Rosenthal, Wendy R. Uhlmann   +7 more
wiley   +1 more source

Bilateral association between muscle strength and depression: evidence from a prospective cohort study

BMC Public Health
Background Both low muscle strength and depressive symptoms are common among middle-aged and older adults. However, their bilateral association has not been thoroughly investigated.
Tong Guo, Fanchao Meng, Sixiang Liang, Guangwei Zhao, Jun Liu, Xue Wang, Ling Zhang, Gang Wang   +7 more
doaj   +1 more source

The effects of childhood trauma on personality in unaffected first-degree relatives of patients with major depressive disorder

BMC Psychiatry, 2022
Abstrac Objectives This study aimed to preliminarily and exploratorily examine the associations between childhood trauma (CT), its subtypes, and personality traits among unaffected first-degree relatives (FDR, children, or siblings) of patients with ...
Yu-jie Wen, Qi-jing Bo, Wen-peng Hou, Zhen Mao, Feng Li, Fan He, Fang Dong, Xin Ma, Yi-lang Tang, Xian-bin Li, Chuan-yue Wang   +10 more
doaj   +1 more source