Results 51 to 60 of about 12,971,816 (251)

Efficacy and safety of Toludesvenlafaxine extended-release tablets in the treatment of treatment-resistant depression

BMC Psychiatry
Background Treatment-resistant depression (TRD) is a major challenge in clinical psychiatry, characterized by insufficient response to at least two different classes of antidepressants.
Zhang Qi, Guo Xiaowen, Li Wenjie, Kong Xiangqi, Wang Haodong, Zheng Yunshao, Yang Limin, Jian Jia, Sun Mengmeng, Mu Chaojuan, Mi Guolin, Liu Hao, Wang Aizhen, Gao Chunni, Yang Xiaodong, Bai Ludong, Xun Guanglei   +16 more
doaj   +1 more source

Severe Psychological Distress of Evacuees in Evacuation Zone Caused by the Fukushima Daiichi Nuclear Power Plant Accident: The Fukushima Health Management Survey.

PLoS ONE, 2016
BackgroundFollowing the Great East Japan Earthquake on March 11, 2011, the nuclear disaster at the Fukushima Daiichi Nuclear Power Plant has continued to affect the mental health status of residents in the evacuation zone.
Yasuto Kunii, Yuriko Suzuki, Tetsuya Shiga, Hirooki Yabe, Seiji Yasumura, Masaharu Maeda, Shin-Ichi Niwa, Akira Otsuru, Hirobumi Mashiko, Masafumi Abe, Mental Health Group of the Fukushima Health Management Survey   +10 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Jonathan Swift Clinic Approved Centre Inspection Report 28 – 31 March 2017

, 2017
Section 51(1)(a) of the Mental Health Act 2001 (the 2001 Act) states that the principal function of the Inspector shall be to “visit and inspect every approved centre at least once a year in which the commencement of this section falls and to visit and ...
Mental Health Commission (MHC)
core  

Multifactorial, biomarker-based model for assessing the state of patients with schizophrenia

Бюллетень сибирской медицины
Relevance. Objective comparison of biological markers and real clinical presentation is especially difficult in mental disorders, which are classified according to a large number of diagnostic criteria and a wide variety of symptoms.
E. G. Cheremnykh, O. K. Savushkina, T. A. Prokhorova, S. A. Zozulya, I. N. Otman, A. N. Pozdnyakova, N. S. Karpova, Yu. E. Shilov, T. P. Klyushnik   +8 more
doaj   +1 more source

Association between polymorphism of the NEDD4 gene and cognitive dysfunction of schizophrenia patients in Chinese Han population

BMC Psychiatry, 2019
Background Schizophrenia is a complex psychiatric disorder with unknown etiology. A number of recent studies have shown that the polymorphism of the neural precursor cell expressed developmentally down-regulated 4 (NEDD4) gene is associated with a ...
Chao Han, Kaiyan Cui, Xiaojiao Bi, Lina Wang, Mengmeng Sun, Limin Yang, Lanfen Liu   +6 more
doaj   +1 more source

Minocycline as adjunctive treatment for treatment-resistant depression: study protocol for a double blind, placebo-controlled, randomized trial (MINDEP2)

BMC Psychiatry, 2020
Background Available evidence suggests that adjunctive treatment with immunomodulatory medications may be effective in the treatment of major depressive disorder (MDD).
Muhammad Ishrat Husain, Clare Cullen, Madeha Umer, Andre F. Carvalho, Stefan Kloiber, Jeffrey H. Meyer, Abigail Ortiz, Yuliya Knyahnytska, M. Omair Husain, Justine Giddens, Breno S. Diniz, Wei Wang, Allan H. Young, Benoit H. Mulsant, Zafiris J. Daskalakis   +14 more
doaj   +1 more source

Factors Associated With the Rising Trend in Self‐Reported Cognitive Disability Among U.S. Adults Aged 18–39 From 2013–2024

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Building on our prior Behavioral Risk Factor Surveillance System analysis identifying adults aged 18–39 as the primary driver of the national increase in self‐reported cognitive disability, we examined factors associated with this rise using 2013–2024 U.S. BRFSS data. Methods We analyzed U.S.
Adam de Havenon, Ka‐Ho Wong, Mirriam Mananah, Christopher D. Anderson, Ada Fenick, Amy Arnsten, Arman Fesharaki‐Zadeh, James C. McPartland, Mary L. Adams, Kevin N. Sheth   +9 more
wiley   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source