Results 131 to 140 of about 2,527,419 (307)
Advanced Science, EarlyView.Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo +10 more
wiley +1 more source
Cohort Profile: The Tokyo Adolescent Mental Health Study (TAMHS)
Journal of EpidemiologyThe Tokyo Adolescent Mental Health Study (TAMHS) is an ongoing, school-based longitudinal cohort designed to elucidate the developmental trajectories of mental health among adolescents in Japan and to inform evidence-based strategies for promoting ...
Rui Zhou +5 more
doaj +1 more source
Advanced Science, EarlyView.An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu +10 more
wiley +1 more source
Advanced Science, EarlyView.Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng +15 more
wiley +1 more source
Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
Integrating Specialist Judgments With and Without Mentalizing. [PDF]
In daily life, we frequently interact with specialists—individuals whose complementary insights augment our limited first-hand experiences in decision-making. Efficient as this may be, the cognitive demands of employing our theory of mind to determine and integrate the evidential contributions of diverse specialists may offset its benefits.
Zhao, Danqin, Bramley, Neil R.
openaire +1 more source
Advanced Science, EarlyView.RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan +8 more
wiley +1 more source
The Mental Health Commission (MHC) promotes, encourages, and fosters the establishment and maintenance of high standards and good practices in the delivery of mental health services and protects the interests of persons admitted and detained under the ...
Mental Health Commission (MHC)
core
, 2018 Section 51(1)(a) of the Mental Health Act 2001 (the 2001 Act) states that the principal function of the Inspector shall be to “visit and inspect every approved centre at least once a year in which the commencement of this section falls and to visit and ...
Mental Health Commission (MHC)
core
Advanced Science, EarlyView.Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou +13 more
wiley +1 more source