Results 211 to 220 of about 985,813 (263)

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

Adolescent Online Gaming in Jordan: A Cross-Sectional Study on Habits and Health Perceptions Through the Health Belief Model. [PDF]

J Child Adolesc Psychiatr Nurs
Khatatbeh H, Al-Dwaikat T, Khatatbeh M, Premusz V, Khatatbeh M, Alkouri O, Alrida N, AlBashtawy M, Al-Sadoon I, Ali AM.   +9 more
europepmc   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Towards an Integrated Staging Model for Bipolar Disorders: An International Society for Bipolar Disorders (ISBD) Staging Task Force Consensus Report. [PDF]

Bipolar Disord
Kupka R, Hafeman D, McCallum M, van der Markt A, Tremain H, Alda M, Almeida J, Cardoso TA, Balanzá-Martínez V, Birmaher B, Bond DJ, Brietzke E, Chendo I, Grande I, Hajek T, Hillegers M, Kauer-Sant'Anna M, Mansur R, Passos IC, Pinto AG, Post R, Tohen M, Vazquez G, Vieta E, Yatham LN, Kapczinski F, Berk M, Duffy A.   +27 more
europepmc   +1 more source

Masculine Norm Adherence Among Australian Men: Latent Structure of the CMNI-22 and Its Links With Mental Health Outcomes. [PDF]

Health Promot J Austr
Mancini VO, Brett J, Chhabra J, Clarke J, Nevill TP, Preece DA, Seidler Z, Roberts B, Martin S.   +8 more
europepmc   +1 more source

Mental Health Assessments and Models of Care in the Emergency Department: A Narrative Review. [PDF]

Emerg Med Australas
Russell SE, Cole DL, Clarke MM, Mennen M, Rebis S, Horgan L, Vakil K, Choi J.   +7 more
europepmc   +1 more source

Examining the mediating roles of self-esteem and social support in the link between digital addiction and mental health: findings from a meta-analytic structural equation modeling study. [PDF]

Front Public Health
Karaköse T, Tülübaş T, Han B, Kanadli S, Kardas A, Polat H, Demirkol M.   +6 more
europepmc   +1 more source

Digital CBT reduces mental disorders and boosts access to care in college students. [PDF]

Nat Hum Behav
europepmc   +1 more source