Results 201 to 210 of about 25,695,435 (333)

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

The Creation of Shared Mental Models in Simulation Training Enhances Quality of Resuscitation: A Randomized Controlled Study. [PDF]

J Med Educ Curric Dev
Friederich C, Schulte-Unetrop L, Cenaj D, Kröger LF, Küllmei J, Zöllner C, Moll-Khosrawi P.   +6 more
europepmc   +1 more source

Particulate matter in the workplace: effects of a mental models-based folder combined with a practical assignment. [PDF]

BMC Public Health, 2022
Stege TAM, Bolte JFB, Claassen L, Timmermans DRM.   +3 more
europepmc   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Bringing team science to the ambulatory diagnostic process: how do patients and clinicians develop shared mental models? [PDF]

Diagnosis (Berl)
Samost-Williams A, Thomas EJ, Lounsbury O, Tannenbaum SI, Salas E, Bell SK.   +5 more
europepmc   +1 more source

Healthcare worker mental models of patient care tasks in the context of infection prevention and control. [PDF]

Infect Control Hosp Epidemiol, 2022
Mumma JM, Howard-Anderson JR, Morgan JS, Schink K, Wheatley MJ, Kraft CS, Lane MA, Kaufman NH, Ayeni O, Brownsword EA, Jacob JT.   +10 more
europepmc   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Reasoning about possibilities: Modal logics, possible worlds, and mental models. [PDF]

Psychon Bull Rev
Johnson-Laird PN, Ragni M.
europepmc   +1 more source

Some Assembly Required: Player Mental Models of Videogame Avatars. [PDF]

Front Psychol, 2021
Banks J, Bowman ND.
europepmc   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source