Results 101 to 110 of about 14,455,867 (246)
Advanced Science, EarlyView.This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang +11 more
wiley +1 more source
A National Survey from the Office of the Inspector of Mental Health Services
An estimated 51,000 first presentations of acute mental health need are made each year through hospital emergency departments and medical wards in Ireland1 .
Lucey, Professor James V +1 more
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Mental Health Commission Annual Report 2018
, 2019 The 2018 Annual Report focuses on the main developments, achievements and changes in mental health services that occurred during 2018. It also discusses the Commission’s comprehensive stakeholder engagement process that was undertaken to develop a new ...
Mental Health Commission (MHC)
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Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Royal Society Open ScienceNumbers are associated with space, but it is unclear how flexible these associations are. We investigated whether the SNARC effect (Spatial-Numerical Association of Response Codes; Dehaene et al. 1993 J. Exp. Psychol. 122, 371–396. (doi:10.1037/0096-3445.
Lilly Roth +5 more
doaj +1 more source
, 2016 Section 51 (1) (a) of the Mental Health Act (2001). States that the principal function of the Inspector shall be to “visit and inspect every approved centre at least once a year in which the commencement of this section falls and to visit and inspect any
Mental Health Commission (MHC)
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Advanced Science, EarlyView.Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters +12 more
wiley +1 more source
Seclusion, Mechanical Restraint and Physical Restraint Activities Report 2023
The report documents the use of seclusion and restraint across 66 inpatient mental health centres across the country in 2023. It is the fifteenth such publication by the MHC and forms part of its remit to report independently on the quality and safety of
Mental Health Commission (MHC)
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, 2016 The Mental Health Commission strives to ensure its principal legislative functions are achieved through the registration of approved centres. The process for determination of the compliance level of approved centres, against the statutory regulations ...
Mental Health Commission (MHC)
core
Advanced Science, EarlyView.Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang +3 more
wiley +1 more source