Results 61 to 70 of about 2,459,766 (303)

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

open access: yesAdvanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García   +13 more
wiley   +1 more source

Identifying Predictors of Suicide in Severe Mental Illness: A Feasibility Study of a Clinical Prediction Rule (Oxford Mental Illness and Suicide Tool or OxMIS)

open access: yesFrontiers in Psychiatry, 2020
BackgroundOxford Mental Illness and Suicide tool (OxMIS) is a brief, scalable, freely available, structured risk assessment tool to assess suicide risk in patients with severe mental illness (schizophrenia-spectrum disorders or bipolar disorder).
Morwenna Senior   +9 more
doaj   +1 more source

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

open access: yesAdvanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao   +19 more
wiley   +1 more source

Machine Learning-Based Mental Health Classification Using Physiological and Physical Activity Data from Wearable Sensors

open access: yesJurnal Nasional Pendidikan Teknik Informatika (JANAPATI)
Mental health profoundly impacts individuals’ quality of life, productivity, and holistic well-being. The early identification of mental health disorders remains problematic, owing largely to the dependence on subjective evaluation methods.
Didi Supriyadi, Annisa Aprili Monti
doaj   +1 more source

Discrepancy Between Quarterly Recall and Annual Recall of Falls: A Survey of Older Adults

open access: yesAnnals of Geriatric Medicine and Research, 2017
Background : Accurate measurement of the frequency of falls is challenging because falls can only be self-reported. We hypothesized that quarterly surveys over a year would be superior to a 1-time annual survey for older adults to recall the number of ...
Jinho Yoo   +5 more
doaj   +1 more source

Jonathan Swift Clinic Approved Centre Inspection Report 28 – 31 March 2017

open access: yes, 2017
Section 51(1)(a) of the Mental Health Act 2001 (the 2001 Act) states that the principal function of the Inspector shall be to “visit and inspect every approved centre at least once a year in which the commencement of this section falls and to visit and ...
Mental Health Commission (MHC)
core  

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

open access: yesAdvanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu   +5 more
wiley   +1 more source

How informed is our consent? Patient awareness of radiation and radical prostatectomy complications

open access: yesUrology Research and Practice, 2019
Objective: To evaluate patient’s recall of pretreatment counseling for radical prostatectomy and radiation therapy for the treatment of prostate cancer.
Derek J. Lomas   +2 more
doaj   +1 more source

An Expertise Transfer Framework For Autonomous Surgical Assistance

open access: yesAdvanced Science, EarlyView.
This study introduces an expertise transfer framework for procedure‐spanning autonomous surgical assistance. By emulating expert logic through hierarchical perception, attention modeling, and knowledge graph‐based decision‐making, the system provides near‐expert surgical view assistance.
Yuan Gao   +12 more
wiley   +1 more source

Second-Language Vocabulary Learning and the Additivity Hypothesis

open access: yesCanadian Journal of Applied Linguistics, 2002
Paivio's (1975) additivity hypothesis suggests that simultaneous stimuli from different sources enhance the recall of an item. However, little is known about the additivity of pictures and spoken words in reading conditions where participants are allowed
François Pichette
doaj  

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