Results 11 to 20 of about 813 (143)

CII Z factors at MEPC 83, update after ISWG-APEE 1 [PDF]

This briefing sets out the state of play on IMO negotiations on shipping carbon intensity after the April 2025 APEE meeting, before the start of MEPC ...
Bullock, Simon; id_orcid
core   +15 more sources

Metarhizium robertsii ammonium permeases (MepC and Mep2) contribute to rhizoplane colonization and modulates the transfer of insect derived nitrogen to plants. [PDF]

PLoS ONE, 2019
The endophytic insect pathogenic fungi (EIPF) Metarhizium promotes plant growth through symbiotic association and the transfer of insect-derived nitrogen. However, little is known about the genes involved in this association and the transfer of nitrogen.
Soumya Moonjely, Xing Zhang, Weiguo Fang, Michael J Bidochka   +3 more
doaj   +2 more sources

LARP3, LARP7, and MePCE are Involved in the Early Stage of Human Telomerase RNA Biogenesis

Nature Communications, 2023
Abstract Human telomerase assembly is a highly dynamic process. Using biochemical approaches, we found that LARP3 and LARP7/MePCE are involved in the early stage and that their binding to hTR is destabilized when the mature hTR is produced. LARP7 and MePCE knockdown inhibits the conversion of the 3′-extended short (exS) form into mature hTR and
Tsai-Ling Kao, Yu-Cheng Huang, Yi-Hsuan Chen, Peter Baumann, Chi-Kang Tseng   +4 more
openaire   +3 more sources

Structural basis of 7SK RNA 5′-γ-phosphate methylation and retention by MePCE [PDF]

Nature Chemical Biology, 2018
Among RNA 5'-cap structures, γ-phosphate monomethylation is unique to a small subset of noncoding RNAs, 7SK and U6 in humans. 7SK is capped by methylphosphate capping enzyme (MePCE), which has a second nonenzymatic role as a core component of the 7SK ribonuclear protein (RNP), an essential regulator of RNA transcription.
Yuan Yang, Catherine D. Eichhorn, Yaqiang Wang, Duilio Cascio, Juli Feigon   +4 more
openaire   +4 more sources

Impact of ammonium permeases MepA, MepB, and MepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi

In Fusarium fujikuroi, the production of gibberellins and bikaverin is repressed by nitrogen sources such as glutamine or ammonium. Sensing and uptake of ammonium by specific permeases play key roles in nitrogen metabolism.
Tudzynski B, Rutherford JC, Teichert S, Wottawa M, Heitman J   +4 more
core   +5 more sources

A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis [PDF]

Nature Communications, 2021
Abstract Telomerase reverse transcriptase (TERT) and the noncoding telomerase RNA (TR) subunit constitute the core of telomerase. Additional subunits are required for ribonucleoprotein complex assembly and in some cases remain stably associated with the active holoenzyme. Pof8, a member of the LARP7 protein family
Diego J. Páez-Moscoso, David V. Ho, Lili Pan, Katie Hildebrand, Kristi L. Jensen, Michaella J. Levy, Laurence Florens, Peter Baumann   +7 more
openaire   +5 more sources

Catalytic activity of the Bin3/MEPCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster

GENETICS, 2023
ABSTRACT Methylphosphate Capping Enzyme (MEPCE) monomethylates the gamma phosphate at the 5’ end of the 7SK noncoding RNA, a modification thought to protect 7SK from degradation. 7SK serves as a scaffold for assembly of a snRNP complex that inhibits transcription by sequestering the positive elongation factor P-TEFb ...
Ryan J Palumbo, Steven D Hanes
openaire   +4 more sources

JMJD6 Cleaves MePCE to Release P-TEFb [PDF]

, 2019
Abstract More than 30% of genes in higher eukaryotes are regulated by promoter-proximal pausing of RNA polymerase II (Pol II). Phosphorylation of Pol II-CTD by positive transcription elongation factor (P-TEFb) is a necessary precursor event that enables productive transcription elongation.
Lee, Schuyler, Liu, Haolin, Hill, Ryan, Hong, Xia, Liu, Xinjian, Crawford, Fran, Zhang, Qianqian, Kingsley, Molly, Chen, Zhongzhou, Lengeling, Andreas, Bernet, Kathrin, Marrack, Philippa, Kappler, John, Hansen, Kirk, Zhou, Qiang, Li, Chuan-Yuan, Zhang, Gongyi   +16 more
openaire   +1 more source

A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP [PDF]

Nucleic Acids Research, 2009
The 7SK snRNP represents a major reservoir of activity where P-TEFb, a general transcription factor key for RNA polymerase II elongation, can be withdrawn to promote gene expression, cell growth and development. Within this complex, 7SK snRNA is a central scaffold that coordinates key protein-protein interactions and maintains P-TEFb in an inactive ...
Xue, Yuhua, Yang, Zhiyuan（Univ Calif Berkeley）, Zhou, Qiang（Univ Calif Berkeley）, Chen, Ruichuan   +3 more
openaire   +4 more sources

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP [PDF]

Nucleic Acids Research, 2013
Through controlling the nuclear level of active positive transcription elongation factor b (P-TEFb), the 7SK small nuclear RNA (snRNA) functions as a key regulator of RNA polymerase II transcription. Together with hexamethylene bisacetamide-inducible proteins 1/2 (HEXIM1/2), the 7SK snRNA sequesters P-TEFb into transcriptionally inactive ...
Muniz, Lisa, Egloff, Sylvain, Kiss, Tamás   +2 more
openaire   +2 more sources