Results 131 to 140 of about 7,322 (183)
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American Journal of Therapeutics, 2002
Meperidine was initially synthesized as an anticholinergic agent but was soon discovered to have analgesic properties. Although meperidine's anticholinergic effects were demonstrated in vivo, the anticholinergic effects on the biliary and renal tracts have not been demonstrated in vivo.
Kenneth S, Latta +2 more
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Meperidine was initially synthesized as an anticholinergic agent but was soon discovered to have analgesic properties. Although meperidine's anticholinergic effects were demonstrated in vivo, the anticholinergic effects on the biliary and renal tracts have not been demonstrated in vivo.
Kenneth S, Latta +2 more
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American Journal of Psychiatry, 1987
Despite the widespread use of meperidine as an analgesic, its potential for producing delirium has been overlooked. Six cases demonstrating meperidine-induced behavioral toxicity are reported. Toxicity was more likely when meperidine was combined with cimetidine or drugs having anticholinergic activity. Discontinuation of meperidine and substitution of
S J, Eisendrath +4 more
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Despite the widespread use of meperidine as an analgesic, its potential for producing delirium has been overlooked. Six cases demonstrating meperidine-induced behavioral toxicity are reported. Toxicity was more likely when meperidine was combined with cimetidine or drugs having anticholinergic activity. Discontinuation of meperidine and substitution of
S J, Eisendrath +4 more
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Disposition of meperidine in pregnancy
Clinical Pharmacology & Therapeutics, 1978Plasma concentration‐time profiles of meperidine after intravenous administration to 7 pregnant women during labor were investigated. There was considerable interpatient variation in initial plasma concentrations of meperidine and its volume of distribution.
D, Morgan +3 more
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Pharmacokinetics of meperidine in pregnancy
International Journal of Gynecology & Obstetrics, 1989AbstractThe disposition of meperidine was studied in 11 term pregnant humans after the administration of a single 50 mg intravenous dose of meperidine through 48 h post‐injection. Half‐lives of the rapid and terminal elimination phases were calculated as 2.3 and 13.3 h, respectively.
E L, Todd +3 more
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2000
Abstract Meperidine is a synthetic opiate, structurally unlike morphine, that produces morphine-like effects. It is available as a pill or a syrup for oral use and in solution for parenteral use. Originally introduced as a “nonaddicting analgesic,” its ready availability soon led to addiction among physicians and nurses; today, it is ...
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Abstract Meperidine is a synthetic opiate, structurally unlike morphine, that produces morphine-like effects. It is available as a pill or a syrup for oral use and in solution for parenteral use. Originally introduced as a “nonaddicting analgesic,” its ready availability soon led to addiction among physicians and nurses; today, it is ...
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Meperidine and Central Neurotoxicity
Annals of Internal Medicine, 1983Excerpt Kaiko and associates (1) have recently reported inAnnals of Neurologyon the excitatory effects in the central nervous system of meperidine.
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Safety concerns with meperidine
Journal of PeriAnesthesia Nursing, 2002MEPERIDINE, AN OPIOID analgesic that has been used clinically for over 60 years, is metabolized in the liver to meperidinic acid and normeperidine. Normeperidine has a long halflife (14 to 21 hours) that can increase to more than 30 hours in patients with renal failure or elderly patients with renal insufficiency, thereby increasing the risk for ...
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Effects of Age on Meperidine Disposition
Survey of Anesthesiology, 1985Elderly patients appear to be more sensitive to meperidine than younger ones; however, the contributions of altered dynamic and kinetic factors are not clear. Accordingly, seven healthy normal men aged 60 to 79 yr were simultaneously given 25 mg meperidine HCl intravenously and the same dose of deuterium-labeled drug either orally or intramuscularly ...
R J, Herman +3 more
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TRICHLOROETHYLENE AND MEPERIDINE
Journal of the American Medical Association, 1958To the Editor:— The editorial on page 2198 of the Dec. 28 issue ofThe Journalentitled "Obstetric Analgesia and Anesthesia" quotes Dinnick as stating "that trichloroethylene should not be used if the patient has had meperidine." This is not in accord with the beliefs and practices prevailing in the United States.
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