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Neurotoxicity of meperidine

Annals of Emergency Medicine, 1985
Meperidine neurotoxicity manifests as shakiness, tremors, myoclonus, and seizures. It is generally seen with repeated parenteral use. We report a case of meperidine neurotoxicity from oral use by an otherwise healthy woman. The pharmacology and clinical implications are discussed.
M G Goetting, Mark G Goetting
exaly   +3 more sources

Detection of meperidine and its metabolites in the hair of meperidine addicts

Forensic Science International, 1999
Abstract The presence of meperidine and its metabolites in the hair of meperidine addicts was investigated using GC–MS (EI, PCI). Meperidine and its three metabolites – normeperidine, N -methoxy meperidine and acetyl normeperidine, were found in hair samples from addicted subjects.
Xiang Ping
exaly   +2 more sources

INTERACTIONS OF LEVALLORPHAN AND MEPERIDINE

Survey of Anesthesiology, 1969
The respiratory effects of meperidine and levallorphan mixtures were studied in 5 healthy volunteers. The majority of pulmonary function tests and gas uptake studies gave either no evidence of change or only changes typical of opioids in general. Meperidine, 1.65 mg.
J C, Rouge, M P, Banner, T C, Smith
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The Bioavailability of Meperidine Using Urine Assays for Meperidine and Normeperidine

The Journal of Clinical Pharmacology, 1975
The results of a two-way crossover trial of two commercial preparations of meperidine hydrochloride in 24 healthy volunteers is reported. The urinary excretion patterns resulting from dosing with the two preparations were followed for 48 hours, and the urine concentrations of meperidine and a major metabolite, normeperidine, were determined by gas ...
J E, Stambaugh, I W, Wainer
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USE OF MEPERIDINE AND MEPERIDINE-LEVALLORPHAN MIXTURES IN THE RECOVERY ROOM

Journal of the American Medical Association, 1958
In order to collect objective data on the use of narcotic analgesics in the immediate postoperative period, 160 patients who required a narcotic for the relief of pain while in the recovery room were studied by the "double-blind" technique. Meperidine administered in doses of 25 mg.
M S, SADOVE   +3 more
openaire   +2 more sources

Naloxone, Meperidine, and Shivering

Anesthesiology, 1993
Meperidine, which binds both mu and kappa opioid receptors, is reportedly more effective in treating shivering than are equianalgesic doses of morphine (a nearly pure mu-receptor agonist). Furthermore, butorphanol, a kappa-receptor agonist/antagonist, treats shivering better than does fentanyl, which mostly binds mu receptors.
M, Kurz   +6 more
openaire   +2 more sources

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