Results 171 to 180 of about 192,759 (291)

Data‐Driven Engineering of Thermostable Collagen‐Mimetic Peptoid Triple Helices

open access: yesMacromolecular Rapid Communications, EarlyView.
Data‐driven active learning discovery of collagen‐mimetic peptoids capable of forming a thermostable collagen‐like triple helix using computational screening followed by experimental validation. ABSTRACT Collagen‐mimetic peptides (CMPs) are engineered molecules designed to replicate the triple‐helical structure of natural collagen.
Alex Berlaga   +6 more
wiley   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui   +4 more
wiley   +1 more source

Fast barcode calling based on <i>k</i>-mer distances. [PDF]

open access: yesPNAS Nexus
Uphoff RC   +3 more
europepmc   +1 more source

Analysis of the Matrix Metalloproteinases Family Profile in Gastric Cancer Suggests Key Matrix Metalloproteinases for Tumor Development and Their Clinical Impact

open access: yesMolecular Carcinogenesis, EarlyView.
ABSTRACT Gastric cancer (GC) is the fifth most common type worldwide, representing a public health problem. Among the genes related to this tumorigenesis, the family of matrix metalloproteinases (MMPs), essential regulators of the extracellular matrix (ECM), stand out for their involvement in the development and progression of GC.
Aline Costa Bastos   +11 more
wiley   +1 more source

GeneMiner2: Accurate and Automated Recovery of Genes From Genome Skimming Data. [PDF]

open access: yesMol Ecol Resour
Yu X   +7 more
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

open access: yesChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel   +5 more
wiley   +1 more source

The Advantage of Microelectrode Recording When Pneumocephalus Threatens the Precise Placement of a Deep Brain Stimulator. [PDF]

open access: yesTremor Other Hyperkinet Mov (N Y)
Walker-Pizarro N   +7 more
europepmc   +1 more source

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