Results 21 to 30 of about 265,557 (264)

The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old

Scientific Reports, 2021
Successful aging is likely to involve both genetic and environmental factors, but environmental toxicants that accelerate aging are not known. Human exposure to mercury is common, and mercury has genotoxic, autoimmune, and free radical effects which ...
Roger Pamphlett
doaj   +1 more source

Interactions between wild pigs and the spread of disease

eLife
Tracking wild pigs with GPS devices reveals how their social interactions could influence the spread of disease, offering new strategies for protecting agriculture, wildlife, and human health.
Mercury Shitindo
doaj   +1 more source

Sensing Mercury for Biomedical and Environmental Monitoring

Sensors, 2009
Mercury is a very toxic element that is widely spread in the atmosphere, lithosphere, and surface water. Concentrated mercury poses serious problems to human health, as bioaccumulation of mercury within the brain and kidneys ultimately leads to ...
Julia Xiaojun Zhao, E. Michael Collins, Hanying Xu, Paul D. Selid, Marla Striped Face-Collins   +4 more
doaj   +1 more source

A comprehensive sulfate and DOM framework to assess methylmercury formation and risk in subtropical wetlands

Nature Communications
Wetlands play a vital role in contaminant cycling and uptake. Understanding how sulfate (SO4 2‒) influences the conversion of inorganic mercury (Hg(II)) to toxic methylmercury (MeHg) is critical for predicting wetland responses to land use and climate ...
Brett A. Poulin, Michael T. Tate, Sarah E. Janssen, George R. Aiken, David P. Krabbenhoft   +4 more
doaj   +1 more source

A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

EMBO Molecular Medicine, 2014
5′AMP‐activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) characterized by increased lipogenesis and activation of mTORC1 pathway. However, whether
Giorgia Zadra, Cornelia Photopoulos, Svitlana Tyekucheva, Pedram Heidari, Qing Ping Weng, Giuseppe Fedele, Hong Liu, Natalia Scaglia, Carmen Priolo, Ewa Sicinska, Umar Mahmood, Sabina Signoretti, Neal Birnberg, Massimo Loda   +13 more
doaj   +1 more source

Occurrence characteristics of mercury in high-mercury coal and distribution rule of mercury in products of an air dense medium fluidized bed

International Journal of Mining Science and Technology, 2018
Mercury emitted from direct combustion of high-mercury coal does great harm to the environment. To make good use of high-mercury coal, it is necessary to study the occurrence characteristics of mercury in coal and high-efficient methods of mercury ...
Guilin Zhang, Shulei Song, Weiqiao Yang, Bo Zhang, Jianqing Wang   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Comparison of Numerical Simulations of Propeller Open-Water Performance with Cavitation for High-Speed Planing Hulls

Journal of Marine Science and Engineering
Numerical simulations of an open-water propeller are performed using CFDShip-Iowa. The propeller, originally designed by Mercury Marine for a 21 feet high-speed planing hull, is scaled to match a 42 feet hull configuration. Three advance ratios (J = 0.8,
Sungtek Park, Zhaoyuan Wang, Frederick Stern, Andrew Gunderson, John Scherer   +4 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Model analyses of atmospheric mercury: present air quality and effects of transpacific transport on the United States [PDF]

Atmospheric Chemistry and Physics, 2013
Atmospheric mercury is a toxic air and water pollutant that is of significant concern because of its effects on human health and ecosystems. A mechanistic representation of the atmospheric mercury cycle is developed for the state-of-the-art global ...
H. Lei, X.-Z. Liang, D. J. Wuebbles, Z. Tao   +3 more
doaj   +1 more source