Results 41 to 50 of about 802,927 (358)

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga   +8 more
wiley   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

open access: yesMolecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin   +10 more
wiley   +1 more source

Environmental Mercury and Its Toxic Effects [PDF]

open access: yesJournal of Preventive Medicine and Public Health, 2014
Mercury exists naturally and as a man-made contaminant. The release of processed mercury can lead to a progressive increase in the amount of atmospheric mercury, which enters the atmospheric-soil-water distribution cycles where it can remain in ...
Kevin M. Rice   +4 more
doaj   +1 more source

Mercury in the environment [PDF]

open access: yes, 1972
Problems in assessing mercury concentrations in environmental materials are discussed. Data for situations involving air, water, rocks, soils, sediments, sludges, fossil fuels, plants, animals, foods, and man are drawn together and briefly evaluated ...
Fulkerson, W.   +3 more
core   +1 more source

Association of the ICH Score With Withdrawal of Life‐Sustaining Treatment Over a 10‐Year Period

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The intracerebral hemorrhage (ICH) score was developed to enhance provider communication and facilitate early severity assessment. We examined the association of the ICH score with mortality and withdrawal of life‐sustaining treatment (WLST) in a large, multicenter stroke registry, and evaluated temporal trends in these associations.
Nina Massad   +15 more
wiley   +1 more source

Virtual or in‐person: does it matter? Comparing pain, function, quality of life, self‐efficacy and physical function outcomes of virtual, hybrid and in‐person GLA:D Canada participants

open access: yesArthritis Care &Research, Accepted Article.
Objective This study aimed to determine if program format (in‐person, virtual, hybrid) results in differences in three‐month outcomes of pain, function, quality of life, self‐efficacy and chair stands in a hip/knee osteoarthritis management program. Methods A secondary analysis of the GLA:DTM Canada database was completed.
Jill Van Damme   +7 more
wiley   +1 more source

MERCURY IN THE BONES. [PDF]

open access: yesJournal of the American Medical Association, 1888
Dear Sir: —InThe Journal, Jan. 21, page 95, column "Book Reviews," and in commendation of " 600 Medical Don'ts," the review says: "To the other 'don'ts ' might be added: Don't imagine that mercury can get into your bones," etc. What then shall we do with authority so high and so generally accepted as Bartholow? In his "Materia Medica," fifth edition,
Joseph Jones, Inquirer
openaire   +2 more sources

Thermogravimetric and distillation studies on mercury, antimony and arsenic sulfides [PDF]

open access: yes, 1975
Thermogravimetric studies were made on naturally occurring sulfides of mercury, antimony and arsenic to determine activation energies and Arrhenius rates of reaction in vacuum and in atmospheres of air and nitrogen. Of the three sulfides only antimony
Rao, P.D., Town, J.W.
core  

Knee crepitus and osteoarthritis features in young adults following traumatic knee injury

open access: yesArthritis Care &Research, Accepted Article.
Objective This study explored the association between knee crepitus and the presence, and worsening, of structural osteoarthritis features and self‐reported outcomes in young adults following traumatic knee injury. Methods One‐year following anterior cruciate ligament reconstruction (ACLR), 112 participants (41 female participants; median age 28 years)
Jamon L Couch   +8 more
wiley   +1 more source

Thermal desorption of mercury from lignite in a high-temperature furnace and in power plant mills

open access: yesInternational Journal of Coal Science & Technology, 2022
In this article, the binding forms of two lignite samples are determined by thermal desorption using a high-temperature furnace. Each mercury compound, such as HgCl2, has a specific binding strength whose decomposition requires a certain thermal energy ...
Anne-Christin Kropp   +2 more
doaj   +1 more source

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