TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng +9 more
wiley +1 more source
New Insight into Mercury Removal from Fish Meat Using a Single-Component Solution Containing cysteine. [PDF]
Strachowski P +4 more
europepmc +1 more source
PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao +24 more
wiley +1 more source
A Novel Composite Material UiO-66-Br@MBC for Mercury Removal from Flue Gas: Preparation and Mechanism. [PDF]
Zhang Z +8 more
europepmc +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Amine-Decorated Methacrylic Acid-based Inverse Vulcanized Polysulfide for Effective Mercury Removal from Wastewater. [PDF]
Ghumman ASM +7 more
europepmc +1 more source
Preparation of magnetic chitosan using local iron sand for mercury removal. [PDF]
Rahmi +3 more
europepmc +1 more source
Inspired by the regulation mechanism of window blinds, this study designs an electromagnetic wave‐absorbing metamaterial. By introducing the magneto‐electric coupling concept and integrating it with an artificial intelligence‐based data‐driven collaborative optimization strategy, the material optimizes impedance matching performance and enhances loss ...
Zhe Wang +9 more
wiley +1 more source
Fe‐rich NiFe‐LDH catalysts derived from MOFs, showing superior OER activity via lattice oxygen mechanism activation. ABSTRACT Developing a durable and efficient oxygen evolution reaction (OER) catalyst without noble metals is essential for the economical and sustainable production of hydrogen by alkaline water electrolysis.
Nithinraj Panangattu Dharmarajan +12 more
wiley +1 more source
Optimization of divalent mercury removal from synthetic wastewater using desirability function in central composite design of response surface methodology. [PDF]
Bayuo J, Rwiza MJ, Mtei KM.
europepmc +1 more source

