Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Determinants of European cross-border mergers and acquisitions [PDF]
This paper investigates the determinants of European cross-border M&As using a large database. Specifically, we identify some of the different factors which contribute to the efficiency of the firms and divide these into two groups: those which can be ...
Miriam Manchin
core
The economic geographies of mergers and acquisitions (M&As). [PDF]
Environ Plan A, 2023 Keenan L, Wójcik D.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
CREATING OR DESTROYING VALUE THROUGH MERGERS AND ACQUISITIONS? [PDF]
Annals of the University of Oradea: Economic Science, 2015 The avalanche of operations performed and their specificities revealed several motivations for mergers and acquisitions However, although they are concluded with the purpose of value creation, reality has shown that in many cases it was exactly the ...
Sehleanu Mariana
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Mergers, acquisitions and technological regimes: the European experience over the period 2002-2005 [PDF]
Comparisons by countries and by sectors of mergers and acquisitions have usually been performed in separate fields of research. A first group of studies, focusing on international comparisons, has explored the role of corporate governance systems ...
Mirella Daminai, Fabrizio Pompei
core
Mergers and acquisitions: does performance depend on managerial ability? [PDF]
J Innov Entrep, 2023 Suryaningrum DH +3 more
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The Valuation Impact of Financial Advisors: An Empirical Analysis of REIT Mergers and Acquisitions [PDF]
This paper analyzes the effect of financial advisor-monitors on the valuation of real estate investment trust (REIT) mergers. Advisor choice determinants and the effect of advisors on transaction value are examined using a sample of REIT mergers for the ...
Richard A. Phillips, Kenneth Daniels
core