Results 51 to 60 of about 59,240 (312)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Citizens National Bank Building, Meridian, Miss. [PDF]

, 2019
Drawing of bank building in Meridian, MS with people in the streethttps://egrove.olemiss.edu/rayburn/1348/thumbnail ...
Edwards Cigar & News Store (Meridian, Miss.)
core  

Meridian: The Apwt Drunken Boat Anthology of New Writing [PDF]

, 2020
Poetry. Fiction. Literary Nonfiction. Asian & Asian American Studies. California Interest. MERIDIAN: THE APWT DRUNKEN BOAT ANTHOLOGY OF NEW WRITING is a rousing collection of 37 voices, both established and emerging, from over 14 countries.No Full ...
Breen, Sally, Tomlinson, Tim, Shankar, Ravi   +2 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Looking from Union Depot, Meridian, Miss. [PDF]

, 2019
Image of crowd, debris and rail tracks; image of the aftermath of the 1906 tornado in Meridian, MShttps://egrove.olemiss.edu/rayburn/1451/thumbnail ...
G. M. Heiss & Son (Meridian, Miss.)
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Meridian (Meridian Village) [PDF]

, 2019
In the Pathfinder era, Meridian used to be a forested world hosting the Meridian Village Grand Prix race track. Now the planet is stripped of trees, its name has changed, and the Meridian Village player-base has relocated itself an hour's walk away, the ...
Andrew Reinhard
core   +1 more source

Preliminary Evidence of Circadian Rhythms in the Twelve Meridians Using Infrared Thermal Imaging: A Case Series

Photonics
This preliminary study explored circadian variations in meridian-associated skin temperature using infrared thermal imaging (IRTI). Four healthy adults receive a two-hour IRTI measurement alternately over a 24 h period, with thermal images acquired every
Jih-Huah Wu, Fu-Chien Chiu, Yi-Chia Shan, Chuan-Tsung Su   +3 more
doaj   +1 more source

Paradigm transformation from structural meridians to functional meridians: a hypothesis of “the brain controls the meridians”

针刺研究, 2022
The “meridian” is the core concept of acupuncture medicine. It can be said that almost all the theories and clinical practice of acupuncture and moxibustion in traditional Chinese medicine are based on this concept.
ZHANG Shu-jian, RONG Pei-jing
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Looking West from Armour Packing Co., Meridian, Miss. [PDF]

, 2019
Image of the aftermath of the 1906 tornado in Meridian, MShttps://egrove.olemiss.edu/rayburn/1455/thumbnail ...
G. M. Heiss & Son (Meridian, Miss.)
core