Results 261 to 270 of about 746,570 (361)

Letter to the Editor: Chest X-ray-based severity scores in COVID-19 - what do they tell us about oxygen needs? [PDF]

World J Crit Care Med
Khandelwal A, Karim HMR, Bhattacharjee A.   +2 more
europepmc   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Trends in discharge to hospice after critical illness among US Medicare beneficiaries, 2011-2023. [PDF]

Ann Am Thorac Soc
Law AC, Bosch NA, Song Y, Tale AP, Nelson J, Wadhera RK, Barnato AE, Walkey AJ.   +7 more
europepmc   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Genetic merit of sires for ad libitum residual feed intake has no adverse effects on carcass and ham quality traits of restricted-fed heavy pigs. [PDF]

PLoS One
Mondin C, Faggion S, Bonfatti V, Gallo L, Giannuzzi D, Schiavon S, Carnier P.   +6 more
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Recent advancement in prediction of thermoelectric performance in two-dimensional telluride monolayers. [PDF]

iScience
Singh AK, Kumar S, Galvão DS, Kundu TK, Tiwary CS.   +4 more
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Development and Performance Assessment of Single- and Double-Layer TbAG:Ce and YAG:Ce Composite Scintillators on GAGG:Ce Substrates for Optimized α-γ Discrimination and Pulse-Shape Analysis. [PDF]

Materials (Basel)
Bachiri A, Syntfeld-Każuch A, Gorbenko V, Witkiewicz-Lukaszek S, Zorenko T, Syrotych Y, Adamowski L, Swiderski L, Stasiv V, Zhydachevskyy Y, Zorenko Y.   +10 more
europepmc   +1 more source