Results 131 to 140 of about 85,740 (261)

Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4

open access: yesViruses, 2019
The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and caused continual outbreaks worldwide with high mortality. However, no effective anti-MERS-CoV drug is currently available.
Shuai Xia   +9 more
doaj   +1 more source

The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Does Not Replicate in Syrian Hamsters [PDF]

open access: yes, 2013
In 2012 a novel coronavirus, MERS-CoV, associated with severe respiratory disease emerged in the Arabian Peninsula. To date, 55 human cases have been reported, including 31 fatal cases.
Baseler, L. (Laura)   +11 more
core   +5 more sources

Machine Learning‐Guided Repositioning of a SARS‐CoV‐2‐Targeting Molecular Series as Cruzain Inhibitors

open access: yesChemMedChem, Volume 21, Issue 2, January 2026.
An ExtraTrees machine learning (ML) model is used to reposition a SARS‐CoV‐2‐directed library of peptidomimetic compounds as cruzain inhibitors for Chagas disease. Potent binders with a novel P1 moiety (for cruzain) are identified and validated by calorimetry.
Rafael F. Lameiro   +10 more
wiley   +1 more source

Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Healthcare Personnel

open access: yesEmerging Infectious Diseases, 2016
Healthcare settings can amplify transmission of Middle East respiratory syndrome coronavirus (MERS-CoV), but knowledge gaps about the epidemiology of transmission remain.
Basem M. Alraddadi   +15 more
doaj   +1 more source

Single-domain antibodies and their formatting to combat viral infections [PDF]

open access: yes, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies   +4 more
core   +2 more sources

Electrochemical Detection of SARS‐CoV‐2 in Saliva Using ZnO Nanorods Functionalized with Gold‐Conjugated Antireceptor‐Binding Domain Antibodies

open access: yesChemNanoMat, Volume 12, Issue 1, January 2026.
An electrochemical immunosensor based on ZnO nanorods functionalized with gold nanoparticle‐conjugated anti‐receptor‐binding domain antibodies enables rapid, noninvasive, and selective detection of SARS‐CoV‐2 in saliva, providing a promising platform for point‐of‐care diagnostic applications.
Fabíola Lelis de Castro   +15 more
wiley   +1 more source

Replicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection

open access: yesInternational Journal of Infectious Diseases, 2018
Background: Information on the duration of replicative Middle East respiratory syndrome coronavirus (MERS-CoV) shedding is important for infection control. The detection of MERS-CoV sub-genomic mRNAs indicates that the virus is replicative.
Wan Beom Park   +11 more
doaj   +1 more source

Spread of Mutant Middle East Respiratory Syndrome Coronavirus with Reduced Affinity to Human CD26 during the South Korean Outbreak [PDF]

open access: yes
The newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe respiratory infection with a high mortality rate (similar to 35%).
Aigerim, A   +16 more
core   +1 more source

MERS-CoV nsp1 regulates autophagic flux via mTOR signalling and dysfunctional lysosomes

open access: gold, 2022
Yujie Feng   +9 more
openalex   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

open access: yesSmall Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N   +2 more
wiley   +1 more source

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