Results 111 to 120 of about 252,954 (227)

Integrating One Health Into Health Systems: A Systematic Review and Narrative Synthesis of Implementation Challenges, Opportunities and Strategic Directions

Public Health Challenges, Volume 5, Issue 2, June 2026.
This systematic review synthesizes global evidence on the integration of One Health into national health systems. It identifies key system‐level barriers, including governance fragmentation, financing constraints, workforce limitations, and policy gaps, alongside emerging opportunities such as institutional support and multisectoral collaboration.
Md. Shahidul Islam, Nusrat Jahan, Daniel Teshome Gebeyehu   +2 more
wiley   +1 more source

Genetically modified mouse models for SARS-CoV, MERS-CoV, SARS-CoV-2.

Genetically modified mouse models for SARS-CoV, MERS-CoV, SARS-CoV-2.
Muhui Ye (17827313), Fengwei Zhang (358203), Zachary Thomas Freeman (17827316), Yang Wang (5921), Hong Yu (6528), Xianwei Ye (6652394), Yongqun He (20286)   +6 more
core   +1 more source

New MERS-CoV Vaccine

, 2023
The present invention relates to a mutant receptor-binding domain (MERS-mRBD) of MERS-CoV (middle east respiratory syndrome coronavirus) or a fragment thereof and a mutant spike protein (MERS-mSpike) of MERS-CoV or a fragment thereof.
Vásquez García, C., Olsson, S., de la Rosa, K., Silvis, C.   +3 more
core  

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Table_1_Comparative transcriptome analysis of SARS-CoV-2, SARS-CoV, MERS-CoV, and HCoV-229E identifying potential IFN/ISGs targets for inhibiting virus replication.XLSX

, 2023
IntroductionSince its outbreak in December 2019, SARS-CoV-2 has spread rapidly across the world, posing significant threats and challenges to global public health.
Tianyi Lu (2812831), Chunlai Jiang (203935), Fei Chen (13690), Yuzhuang Liu (17602935), Liya Yue (5640293), Cuidan Li (5640287), Xiaotong Wang (276499)   +6 more
core   +1 more source

Host-directed therapies for improving poor treatment outcomes associated with the middle east respiratory syndrome coronavirus infections

International Journal of Infectious Diseases, 2015
Three years after its first discovery in Jeddah Saudi Arabia, the novel zoonotic pathogen of humans, the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) continues to be a major threat to global health security.1 Sporadic community acquired cases ...
Alimuddin Zumla, Esam I. Azhar, Yaseen Arabi, Badriah Alotaibi, Martin Rao, Brian McCloskey, Eskild Petersen, Markus Maeurer   +7 more
doaj   +1 more source

Structural analysis of the flexibility of the Ubl2 domain within the papain‐like protease of SARS‐CoV‐2

Acta Crystallographica Section F, Volume 82, Issue 6, Page 222-230, June 2026.
The ubiquitin‐like domain 2 (Ubl2) of the SARS‐CoV‐2 virus is necessary for the stability and catalytic efficiency of its papain‐like protease (PLpro). Our crystallographic study reveals that the Ubl2 domain exhibits notable flexibility and can adopt a conformation that places itself away from the PLpro catalytic domain, representing a new conformation
Gian Luca Freiherr von Scholley, Martina Schaefer, Mark D. Tully, Marc-Andre Hograindleur, Montserrat Soler-López, Roman C. Hillig, Christoph Mueller-Dieckmann, Eaazhisai Kandiah   +7 more
wiley   +1 more source

Table_2_Comparative transcriptome analysis of SARS-CoV-2, SARS-CoV, MERS-CoV, and HCoV-229E identifying potential IFN/ISGs targets for inhibiting virus replication.XLSX

, 2023
IntroductionSince its outbreak in December 2019, SARS-CoV-2 has spread rapidly across the world, posing significant threats and challenges to global public health.
Tianyi Lu (2812831), Chunlai Jiang (203935), Fei Chen (13690), Yuzhuang Liu (17602935), Liya Yue (5640293), Cuidan Li (5640287), Xiaotong Wang (276499)   +6 more
core   +1 more source

Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels

Emerging Microbes and Infections, 2019
Dromedary camels are important reservoir hosts of various coronaviruses, including Middle East respiratory syndrome coronavirus (MERS-CoV) that cause human infections.
Wei Zhang, Xiao-Shuang Zheng, Bernard Agwanda, Sheila Ommeh, Kai Zhao, Jacqueline Lichoti, Ning Wang, Jing Chen, Bei Li, Xing-Lou Yang, Shailendra Mani, Kisa-Juma Ngeiywa, Yan Zhu, Ben Hu, Samson Omondi Onyuok, Bing Yan, Danielle E. Anderson, Lin-Fa Wang, Peng Zhou, Zheng-Li Shi   +19 more
doaj   +1 more source

Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study

Aging Cell, Volume 25, Issue 6, June 2026.
Can we boost vaccine responses in older adults? In a double‐blind, randomised, placebo‐controlled pilot study (n = 40, > 65 years), spermidine supplementation (6 mg/day, 13 weeks) was safe and significantly improved immune responses following a 3rd SARS‐CoV‐2 vaccine dose.
Ghada Alsaleh, Mohammad Ali, Amir Hossein Kayvanjoo, Feng Liu, Tanaïs Moreau, Sagida Bibi, Lin Luo, Melissa Govender, Miles Carroll, Sebastian J. Hofer, Eisenberg Tobias, Christoph Magnes, Loren Kell, Christopher Chung, Yu Deng, Aneesha Bhandari, Lucy Garner, Thomas Conrad, Liye Chen, Barbara Kronsteiner‐Dobramysl, Susie Dunachie, Owen B. Spiller, Teresa Lambe, Paul Klenerman, Lucy C. Jones, A. Katharina Simon   +25 more
wiley   +1 more source